| Pharmacological assessment of adrenergic receptors in human varicose veins. | |
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MedLine Citation:
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PMID: 10905803 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Experiments were to characterize pharmacologically adrenergic receptors in human varicose veins to the natural transmitter norepinephrine and to an extract of Ruscus. METHODS: Greater saphenous veins and varicose tributaries from patients undergoing elective surgery for primary varicose disease and portions of greater saphenous veins from patients undergoing peripheral arterial reconstruction (control) were suspended for the measurement of isometric force in organ chambers. Concentration response curves were obtained to norepinephrine or the extract of Ruscus aculeatus in the absence and presence of selective antagonists of alpha, and alpha2 adrenergic receptors. RESULTS: Norepinephrine and Ruscus extract caused concentration-dependent contractions in all veins. Contractions to norepinephrine were greater in control veins than in varicose tributaries. Contractions to the extract were greater in varicose tributaries than in greater saphenous veins from varicose patients. Contractions to norepinephrine were reduced similarly by alpha and alpha2-adrenergic agonists in control and varicose veins but to a greater extent by alpha2-blockade in greater saphenous veins from varicose patients. Contractions to Ruscus extract were not reduced by alpha-adrenergic blockade in control veins but were reduced by alpha2-adrenergic blockade in varicose veins. CONCLUSIONS: These results suggest a differential distribution of alpha adrenergic receptors on greater saphenous veins from non-varicose patients compared to those with primary varicose disease. Venotropic agents from plant extract probably exert effects by way of multiple receptor and non-receptor mediated events. |
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Authors:
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V M Miller; K S Rud; P Gloviczki |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International angiology : a journal of the International Union of Angiology Volume: 19 ISSN: 0392-9590 ISO Abbreviation: Int Angiol Publication Date: 2000 Jun |
Date Detail:
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Created Date: 2000-12-13 Completed Date: 2000-12-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8402693 Medline TA: Int Angiol Country: ITALY |
Other Details:
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Languages: eng Pagination: 176-83 Citation Subset: IM |
Affiliation:
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Department of Surgery, Mayo Clinic and Foundation, Rochester, MN 55905, USA. miller.virginia@mayo.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Agonists
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pharmacology Aged Case-Control Studies Female Humans Male Middle Aged Norepinephrine / pharmacology Plant Extracts / pharmacology Receptors, Adrenergic, alpha / analysis, drug effects* Saphenous Vein / chemistry* Varicose Veins / metabolism*, surgery Vasoconstriction / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Agonists; 0/Plant Extracts; 0/Receptors, Adrenergic, alpha; 51-41-2/Norepinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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