Document Detail


Pharmacological assessment of adrenergic receptors in human varicose veins.
MedLine Citation:
PMID:  10905803     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Experiments were to characterize pharmacologically adrenergic receptors in human varicose veins to the natural transmitter norepinephrine and to an extract of Ruscus. METHODS: Greater saphenous veins and varicose tributaries from patients undergoing elective surgery for primary varicose disease and portions of greater saphenous veins from patients undergoing peripheral arterial reconstruction (control) were suspended for the measurement of isometric force in organ chambers. Concentration response curves were obtained to norepinephrine or the extract of Ruscus aculeatus in the absence and presence of selective antagonists of alpha, and alpha2 adrenergic receptors. RESULTS: Norepinephrine and Ruscus extract caused concentration-dependent contractions in all veins. Contractions to norepinephrine were greater in control veins than in varicose tributaries. Contractions to the extract were greater in varicose tributaries than in greater saphenous veins from varicose patients. Contractions to norepinephrine were reduced similarly by alpha and alpha2-adrenergic agonists in control and varicose veins but to a greater extent by alpha2-blockade in greater saphenous veins from varicose patients. Contractions to Ruscus extract were not reduced by alpha-adrenergic blockade in control veins but were reduced by alpha2-adrenergic blockade in varicose veins. CONCLUSIONS: These results suggest a differential distribution of alpha adrenergic receptors on greater saphenous veins from non-varicose patients compared to those with primary varicose disease. Venotropic agents from plant extract probably exert effects by way of multiple receptor and non-receptor mediated events.
Authors:
V M Miller; K S Rud; P Gloviczki
Related Documents :
2565133 - Adrenergic mediated phosphatidylinositol metabolism is modulated by epileptic discharge...
6147403 - Assessment of the functional role of brain adrenergic neurons: chronic effects of pheny...
11346643 - Antagonism of inhalant and volatile anesthetic enhancement of glycine receptor function.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International angiology : a journal of the International Union of Angiology     Volume:  19     ISSN:  0392-9590     ISO Abbreviation:  Int Angiol     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-12-13     Completed Date:  2000-12-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8402693     Medline TA:  Int Angiol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  176-83     Citation Subset:  IM    
Affiliation:
Department of Surgery, Mayo Clinic and Foundation, Rochester, MN 55905, USA. miller.virginia@mayo.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Agonists / pharmacology
Aged
Case-Control Studies
Female
Humans
Male
Middle Aged
Norepinephrine / pharmacology
Plant Extracts / pharmacology
Receptors, Adrenergic, alpha / analysis,  drug effects*
Saphenous Vein / chemistry*
Varicose Veins / metabolism*,  surgery
Vasoconstriction / drug effects
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Plant Extracts; 0/Receptors, Adrenergic, alpha; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Elevated levels of soluble E-selectin in diabetic patients with severe symptomatic peripheral arteri...
Next Document:  Expanding NEURON's repertoire of mechanisms with NMODL.