Document Detail


Pharmacological approaches to methamphetamine dependence: a focused review.
MedLine Citation:
PMID:  20565449     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Methamphetamine dependence is a serious worldwide public health problem with major medical, psychiatric, socioeconomic and legal consequences. Various neuronal mechanisms implicated in methamphetamine dependence have suggested several pharmacological approaches. A literature search from a range of electronic databases (PubMed, EMBASE, PsycInfo, the NIDA research monograph index and the reference list of clinicaltrials.gov) was conducted for the period from January 1985 to October 2009. There were no restrictions on the identification or inclusion of studies in terms of publication status, language and design type. A variety of medications have failed to show efficacy in clinical trials, including a dopamine partial agonist (aripiprazole), GABAergic agents (gabapentin) and serotonergic agents (SSRI, ondansetron, mirtazapine). Three double-blind placebo-controlled trials using modafinil, bupropion and naltrexone have shown positive results in reducing amphetamine or methamphetamine use. Two studies employing agonist replacement medications, one with d-amphetamine and the other with methylphenidate, have also shown promise. Despite the lack of success in most studies to date, increasing efforts are being made to develop medications for the treatment of methamphetamine dependence and several promising agents are targets of further research.
Authors:
Laurent Karila; Aviv Weinstein; Henri-Jean Aubin; Amine Benyamina; Michel Reynaud; Steven L Batki
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  69     ISSN:  1365-2125     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-22     Completed Date:  2010-12-06     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  578-92     Citation Subset:  IM    
Affiliation:
Addiction Research and Treatment Center, Paul Brousse Hospital, Paris XI University, AP-HP, CEA- INSERM U1000, Villejuif, France. laurent.karila@pbr.aphp.fr
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MeSH Terms
Descriptor/Qualifier:
Amphetamine-Related Disorders / drug therapy*
Animals
Antipsychotic Agents / therapeutic use*
Calcium Channel Blockers / therapeutic use
Humans
Immunotherapy
Methamphetamine*
Narcotic Antagonists / therapeutic use
Neurotransmitter Agents / therapeutic use*
Rats
Grant Support
ID/Acronym/Agency:
5R01 DA016764-05/DA/NIDA NIH HHS; U10 DA015815/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Antipsychotic Agents; 0/Calcium Channel Blockers; 0/Narcotic Antagonists; 0/Neurotransmitter Agents; 537-46-2/Methamphetamine
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