Document Detail

Pharmacological analysis of vasoconstrictor responses of isolated and perfused human umbilical arteries.
MedLine Citation:
PMID:  1800478     Owner:  NLM     Status:  MEDLINE    
Using the cannula inserting method, we studied vascular responses of isolated human umbilical arteries to several vasoactive substances. ACh did not produce a vasodilation in non-constricted preparations but induced only a vasoconstriction. Histamine and 5HT produced strong vasoconstrictions in a dose-dependent manner. Epinephrine and norepinephrine in large doses induced only a slight vasoconstriction. The ACh-induced vasoconstriction was markedly suppressed by atropine and slightly, but significantly, suppressed by methylsergide. The vascular responses to ACh were not influenced by removal of the endothelium by an intraluminal bolus injection of saponin. These results suggest that the endothelium has no muscarinic receptors in the umbilical arteries, although cholinergic vasoconstrictor mechanisms may be partially involved in the regulation of umbilical circulation, and that human umbilical arteries exhibit different pharmacological responses from those of vessels of other organs.
F Yoshikawa; S Chiba
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Heart and vessels     Volume:  6     ISSN:  0910-8327     ISO Abbreviation:  Heart Vessels     Publication Date:  1991  
Date Detail:
Created Date:  1992-04-23     Completed Date:  1992-04-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8511258     Medline TA:  Heart Vessels     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  197-202     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Shinshu University School of Medicine, Matsumoto, Japan.
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MeSH Terms
Acetylcholine / pharmacology
Atropine / pharmacology
Dose-Response Relationship, Drug
Epinephrine / pharmacology
Histamine / pharmacology
Methysergide / pharmacology
Norepinephrine / pharmacology
Receptors, Muscarinic / drug effects
Saponins / pharmacology
Serotonin / pharmacology
Umbilical Arteries / drug effects*
Vasoconstriction / drug effects
Vasoconstrictor Agents / administration & dosage,  pharmacology*
Reg. No./Substance:
0/Receptors, Muscarinic; 0/Saponins; 0/Vasoconstrictor Agents; 361-37-5/Methysergide; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 51-45-6/Histamine; 51-55-8/Atropine; 51-84-3/Acetylcholine

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