| Pharmacological analysis of responses to ATP in the isolated and perfused canine coronary artery. | |
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MedLine Citation:
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PMID: 9369346 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vascular responses of the isolated and perfused canine coronary artery to adenosine 5'-triphosphate (ATP) were analyzed pharmacologically. At basal perfusion pressure, ATP induced a vasoconstriction followed by a vasodilation dose-dependently. The potency order for vasoconstriction was alpha,beta-methylene ATP > 2-methylthio ATP > UTP > ATP. That for vasodilation was ATP > 2-methylthio ATP > alpha,beta-methylene ATP >> UTP in the preparations precontracted by 20 mM KCl. Aminophylline inhibited the vasodilation induced by adenosine, but not that induced by ATP. Alpha,beta-methylene ATP and suramin inhibited the vasoconstriction induced by ATP. Reactive blue 2 inhibited the vasodilation induced by ATP, but not the vasoconstriction. Removal of the endothelium by saponin and L-N(G)-nitroarginine inhibited the vasodilation induced by ATP, but indomethacin did not. The results suggest that ATP induces vasoconstriction via P2X purinoceptors on the smooth muscle and vasodilation via P2Y purinoceptors on the endothelium through mainly the release of nitric oxide in the canine coronary artery, respectively. |
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Authors:
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T Matsumoto; T Nakane; S Chiba |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: European journal of pharmacology Volume: 334 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1997 Sep |
Date Detail:
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Created Date: 1998-01-22 Completed Date: 1998-01-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 173-80 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Shinshu University School of Medicine, Asahi, Matsumoto, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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pharmacology* Animals Coronary Vessels / drug effects*, physiology Cyclooxygenase Inhibitors / pharmacology Dogs Endothelium, Vascular / physiology Epoprostenol / antagonists & inhibitors Female Male Muscle, Smooth, Vascular / drug effects*, physiology Nitric Oxide / antagonists & inhibitors Nitric Oxide Synthase / antagonists & inhibitors Perfusion Receptors, Purinergic P1 / antagonists & inhibitors, physiology Receptors, Purinergic P2 / antagonists & inhibitors, physiology Vasoconstriction / drug effects* Vasodilation / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Cyclooxygenase Inhibitors; 0/Receptors, Purinergic P1; 0/Receptors, Purinergic P2; 10102-43-9/Nitric Oxide; 35121-78-9/Epoprostenol; 56-65-5/Adenosine Triphosphate; EC 1.14.13.39/Nitric Oxide Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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