Document Detail

Pharmacological analysis of the effect of KRN2391 on coronary vasculature in perfused rat heart.
MedLine Citation:
PMID:  7926593     Owner:  NLM     Status:  MEDLINE    
1. The antagonism by glibenclamide of the effects of KRN2391, cromakalim and nifedipine on coronary flow (CF) were compared in isolated perfused rat hearts. 2. KRN2391, cromakalim and nifedipine increased CF in a concentration-dependent manner. In the presence of glibenclamide, the concentration-effect curves on CF for KRN2391 and cromakalim shifted to the right but that for nifedipine did not change. 3. The EC50 values increased about 6.6-fold for KRN2391 and 19.0-fold for cromakalim in the presence of glibenclamide. 4. These results suggest that the increase in CF induced by KRN2391 is due to both glibenclamide-sensitive and insensitive mechanisms.
A Miwa; Y Jinno; T Yokoyama; T Izawa; N Ogawa
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  General pharmacology     Volume:  25     ISSN:  0306-3623     ISO Abbreviation:  Gen. Pharmacol.     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-11-10     Completed Date:  1994-11-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7602417     Medline TA:  Gen Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  471-4     Citation Subset:  IM    
Pharmaceutical Research Laboratory, Kirin Brewery Co. Ltd., Gunma, Japan.
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MeSH Terms
Benzopyrans / antagonists & inhibitors,  pharmacology
Coronary Circulation / drug effects*
Dose-Response Relationship, Drug
Glyburide / pharmacology
Nifedipine / antagonists & inhibitors,  pharmacology
Potassium Channels / drug effects*
Pyridines / antagonists & inhibitors,  pharmacology*
Pyrroles / antagonists & inhibitors,  pharmacology
Rats, Wistar
Vasodilator Agents / antagonists & inhibitors,  pharmacology*
Reg. No./Substance:
0/Benzopyrans; 0/Potassium Channels; 0/Pyridines; 0/Pyrroles; 0/Vasodilator Agents; 10238-21-8/Glyburide; 134431-49-5/N-cyano-N'-(2-nitroxyethyl)-3-pyridinecarboximidamide methanesulfonate; 21829-25-4/Nifedipine; 94470-67-4/Cromakalim

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