Document Detail


Pharmacological activities of stromata of Cordyceps scarabaecola.
MedLine Citation:
PMID:  12672154     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The chemical components of freeze-dried stromata from Cordyceps scarabaecola were examined. The stromata consisted of crude carbohydrates (55.1%) and crude proteins (14.2%). The stromata were also composed of a low content of crude ash (6.6%) and fat (1.5%). The composition of the carbohydrate in the stromata included a large quantity of glucose (46.6%), mannose (35.4%) and galactose (18.0%). The acidic amino acids such as glutamic acid (32.1 mg/g) and aspartic acid (24.7 mg/g) were present in a large quantity. The extracts of stromata did not reveal any inhibitory activity for AChE in vitro. It was observed that a hot-water extract (HW) of the stromata contributed significantly to the anticoagulant activity (60 s coagulating time) and anticomplementary activity (62% of ITCH50 value). The MeOH-soluble fraction (M) from the freeze-dried stromata inhibited TPA-induced O2- generation as effectively as the positive control, genistine 27%. The hot-water extract (HW) showed the most potent intestinal immune system modulation activity and the MeOH-soluble fraction (M) had intermediate activity.
Authors:
K W Yu; K M Kim; H J Suh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  17     ISSN:  0951-418X     ISO Abbreviation:  Phytother Res     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-04-02     Completed Date:  2003-05-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  244-9     Citation Subset:  IM    
Copyright Information:
Copyright 2003 John Wiley & Sons, Ltd.
Affiliation:
Department of Kimchi and Food Science, Chongju National College of Science and Technology, Jeungpyung 367-701, Korea.
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MeSH Terms
Descriptor/Qualifier:
Acetylcholinesterase / drug effects*
Animals
Bone Marrow Cells / drug effects
Calcium / analysis,  pharmacology
Carbohydrates / analysis,  pharmacology
Chromatography, High Pressure Liquid
Complement Activation / drug effects*
Cordyceps / chemistry*
Fungal Proteins / analysis,  pharmacology
Glycopeptides / analysis,  pharmacology
HL-60 Cells / drug effects,  metabolism
Humans
Intestine, Small / drug effects,  immunology
Lipids / analysis,  pharmacology
Mice
Mice, Inbred C3H
Phytotherapy
Platelet Aggregation / drug effects*
Platelet Aggregation Inhibitors / administration & dosage,  pharmacology*,  therapeutic use
Potassium / analysis,  pharmacology
Superoxides / metabolism
Chemical
Reg. No./Substance:
0/Carbohydrates; 0/Fungal Proteins; 0/Glycopeptides; 0/Lipids; 0/Platelet Aggregation Inhibitors; 11062-77-4/Superoxides; 7440-09-7/Potassium; 7440-70-2/Calcium; EC 3.1.1.7/Acetylcholinesterase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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