| Pharmacological action of FD-008, a new dopamine-beta-hydroxylase inhibitor. | |
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MedLine Citation:
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PMID: 1173034 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of 5-(4'-chlorobutyl)-picolinic acid (FD-008), a new dopamine beta-hydroxylase inhibitor of fusaric acid derivatives, on the central nervous system in mice and rats were investigated. FD-008 and fusaric acid did not show marked effects on spontaneous movement, convulsion, sleeping time, tremor and conditioned avoidance response but lowered the body temperature of rats at 100 mg/kg p.o. FD-008 potentiated the depressive action of ethanol on conditioned avoidance response in spite of the lack of aldehyde dehydrogenase inhibition. FD-008 markedly depressed the performance on a shuttle box and lowered the body temperature in rats after reserpine treatment at a dose at which FD-008 per se had no effect. |
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Authors:
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Y Ishii; K Natsugoe; H Umezawa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Arzneimittel-Forschung Volume: 25 ISSN: 0004-4172 ISO Abbreviation: Arzneimittelforschung Publication Date: 1975 Feb |
Date Detail:
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Created Date: 1975-05-27 Completed Date: 1975-05-27 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372660 Medline TA: Arzneimittelforschung Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 213-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Aldehyde Oxidoreductases / antagonists & inhibitors Animals Avoidance Learning / drug effects Body Temperature / drug effects Depression, Chemical Disulfiram / pharmacology Dopamine beta-Hydroxylase / antagonists & inhibitors* Drug Synergism Electroshock Ethanol / pharmacology Hexobarbital / pharmacology Hydrocarbons, Chlorinated / pharmacology Injections, Subcutaneous Lethal Dose 50 Male Mice Mice, Inbred ICR Motor Activity / drug effects Picolinic Acids / pharmacology* Rats Reserpine / pharmacology Seizures / prevention & control Sleep / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Hydrocarbons, Chlorinated; 0/Picolinic Acids; 50-55-5/Reserpine; 56-29-1/Hexobarbital; 64-17-5/Ethanol; 97-77-8/Disulfiram; EC 1.14.17.1/Dopamine beta-Hydroxylase; EC 1.2.-/Aldehyde Oxidoreductases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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