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Pharmacological Management Of Pda: Oral Versus Intravenous Medications.
MedLine Citation:
PMID:  22794156     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Patent ductus arteriosus is a common problem in very low birth weight infants. Prostaglandin synthesis inhibitors such as indomethacin and ibuprofen are widely used preferred medications for ductal closure but the question of which one should be preferred is controversial. There are some studies in the literature comparing their pharmacokinetics, efficacy, side effects and long-term outcomes. In this review we aimed to focus on prostaglandin synthesis inhibitors with their pharmacodynamic and pharmacokinetic in relation to oral and intravenous forms. Oral ibuprofen seems to be an effective and cheap alternative to the intravenous forms. Studies in extremely low birth weight infants that also evaluate the neurodevelopment will clarify its use.
Authors:
Gamze Demirel; Omer Erdeve; Ugur Dilmen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-09
Journal Detail:
Title:  Current clinical pharmacology     Volume:  -     ISSN:  2212-3938     ISO Abbreviation:  Curr Clin Pharmacol     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101273158     Medline TA:  Curr Clin Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Division of Neonatology, Samsun Maternity and Children Hospital (Samsun Kadın Doğum ve Çocuk, Hastalıkları Hastanesi, Yenidoğan Yoğun Bakım Ünitesi), Samsun, Turkey. kgamze@hotmail.com.
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