Document Detail


The pharmacological management of intrahepatic cholestasis of pregnancy.
MedLine Citation:
PMID:  21352094     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intrahepatic cholestasis of pregnancy is the most common liver disease occurring in the second half of pregnancy, characterized by pruritus and elevated serum bile acids often coupled to abnormal liver tests. Maternal prognosis is favourable with a complete symptom resolution after delivery, while preterm deliveries, fetal respiratory distress and stillbirths may occur. The goal of the pharmacological treatment of the disease is to improve maternal symptoms and biochemical alterations and, most importantly, to reduce fetal adverse events.The present manuscript will review the current knowledge on the pharmacological treatment of intrahepatic cholestasis of pregnancy.
Authors:
Francesco Azzaroli; Laura Turco; Andrea Lisotti; Claudio Calvanese; Giuseppe Mazzella
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current clinical pharmacology     Volume:  6     ISSN:  1574-8847     ISO Abbreviation:  Curr Clin Pharmacol     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-03-09     Completed Date:  2011-06-20     Revised Date:  2011-09-06    
Medline Journal Info:
Nlm Unique ID:  101273158     Medline TA:  Curr Clin Pharmacol     Country:  United Arab Emirates    
Other Details:
Languages:  eng     Pagination:  12-7     Citation Subset:  IM    
Affiliation:
Department of Clinical Medicine, Gastroenterology Unit, St. Orsola-Malpighi Hospitali, University of Bologna, Italy. francesco.azzaroli@unibo.it
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MeSH Terms
Descriptor/Qualifier:
Animals
Bile Acids and Salts / blood
Cholestasis, Intrahepatic / drug therapy*,  etiology,  physiopathology
Female
Humans
Liver Function Tests
Pregnancy
Pregnancy Complications / drug therapy*,  physiopathology
Pregnancy Outcome / epidemiology*
Prognosis
Pruritus / etiology
Chemical
Reg. No./Substance:
0/Bile Acids and Salts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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