| Pharmacological Interventions to Attenuate the Expansion of Abdominal Aortic Aneurysm (AAA) - A Systematic Review. | |
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MedLine Citation:
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PMID: 21330159 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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INTRODUCTION: Is it possible by pharmacological methods to attenuate the expansion rate of abdominal aortic aneurysms? METHOD: An Internet-based systematic literature search was performed to identify published reports on pharmacological methods to influence aneurysmal expansion rate. RESULTS: Of an original 450 articles, 22 remained to review: they included 15 cohort studies with 12,321 patients and seven randomised clinical trials (RCTs) with 1546 patients. Most studies are performed without a pre-study sample size calculation. There is no consistent pattern of pharmacological influence on expansion rate, but statins, non-steroidal anti-inflammatory drugs (NSAIDs) and macrolides should be further evaluated. CONCLUSION: Properly designed RCTs are needed before conclusions can be drawn on the possibility to pharmacologically attenuate aneurysmal expansion and prevent rupture. |
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Authors:
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D Bergqvist |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-15 |
Journal Detail:
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Title: European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery Volume: - ISSN: 1532-2165 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9512728 Medline TA: Eur J Vasc Endovasc Surg Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Ltd. |
Affiliation:
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Department of Surgical Sciences, Section of Surgery, Uppsala University Hospital, SE 751 85 Uppsala, Sweden. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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