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Pharmacological Evaluation of a β-Hydroxyphosphonate Analogue of L- Carnitine in Obese Zucker fa/fa Rats.
MedLine Citation:
PMID:  23039375     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In the present study, we evaluated the effect of an analogue of L-carnitine on parameters involved with Metabolic Syndrome in obese Zucker rats. Twenty-four rats were treated for five weeks with L-carnitine (300 mg/kg) and its analogue at two concentrations (100 and 250 mg/kg) to assess their impact on glucose, triglycerides and cholesterol in liver and blood samples, as well as the amount of liver glycogen. Liver slices were also analysed. The analogue reduced the levels of glucose, triglycerides and cholesterol in liver and the level of triglycerides in serum. At 100 mg/kg, the analogue proved more effective than L-carnitine in improving the biochemical alterations present in liver. The amount of liver glycogen content was higher in obese animals treated with both L-carnitine and the analogue. No changes on insulin and leptin were observed in animals treated. L-carnitine and its analogue reduced the microvesicular fatty infiltration in liver. This study demonstrated that the analogue tested is more potent and efficient than L-carnitine and improves the pharmacological profile of L-carnitine.
Authors:
Jorge Reyes-Esparza; Brissa Mendoza-Rivera; Ricardo De la Cruz-Cordero; Jorge L Rosado; Miguel Ángel Duarte-Vázquez; Mario García Solis; Odón Vite-Vallejo; Lourdes Rodríguez-Fragoso
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-8
Journal Detail:
Title:  Basic & clinical pharmacology & toxicology     Volume:  -     ISSN:  1742-7843     ISO Abbreviation:  Basic Clin. Pharmacol. Toxicol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101208422     Medline TA:  Basic Clin Pharmacol Toxicol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors Basic & Clinical Pharmacology & Toxicology © 2012 Nordic Pharmacological Society.
Affiliation:
Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Colonia Chamilpa, Cuernavaca, Morelos, México.
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