| Pharmacological ascorbic acid suppresses syngeneic tumor growth and metastases in hormone-refractory prostate cancer. | |
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MedLine Citation:
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PMID: 20554995 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: The aim of this study was to test for the influence of ascorbic acid on tumorigenicity and metastases of implanted PAIII prostate cancer adenocarcinoma cells in syngeneic LW rats. MATERIALS AND METHODS: Hormone-refractory prostate cancer PAIII cells were implanted subcutaneously into immunologically intact, Lobund-Wistar (LW) rats. Intraperitoneal pharmacological doses of ascorbic acid were administered each day for the ensuing 30 days. On the 40th day, animals were sacrificed. Local tumor weights were measured, and metastases were counted. RESULTS: At the end of the 40 day experimental period, the primary tumors were found to be significantly reduced in weight (p=0.026). In addition, sub-pleural lung metastases were even more profoundly reduced in number and size (p=0.009). Grossly enlarged ipsilateral lymph node metastases declined from 7 of 15 rats to 1 of 15 rats. CONCLUSION: Pharmacological doses of ascorbic acid suppress tumor growth and metastases in hormone-refractory prostate cancer. |
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Authors:
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Harvey B Pollard; Mark A Levine; Ofer Eidelman; Morris Pollard |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: In vivo (Athens, Greece) Volume: 24 ISSN: 0258-851X ISO Abbreviation: In Vivo Publication Date: 2010 May-Jun |
Date Detail:
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Created Date: 2010-06-17 Completed Date: 2010-08-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8806809 Medline TA: In Vivo Country: Greece |
Other Details:
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Languages: eng Pagination: 249-55 Citation Subset: IM |
Affiliation:
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Department of Anatomy, Physiology and Genetics, Uniformed Services University School of Medicine, USUHS, Bethesda, MD 20814, USA. hpollard@usuhs.mil |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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drug therapy*,
secondary Animals Antioxidants / pharmacology* Ascorbic Acid / pharmacology* Body Weight Intercellular Signaling Peptides and Proteins / metabolism Lung Neoplasms / drug therapy*, secondary Lymphatic Metastasis Male Neoplasm Transplantation Prostatic Neoplasms / drug therapy*, pathology ROC Curve Rats Rats, Wistar |
| Grant Support | |
ID/Acronym/Agency:
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CA 17559/CA/NCI NIH HHS; N01-HV-28187/HV/NHLBI NIH HHS; RR00294/RR/NCRR NIH HHS; Z01 DK053212-02/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Intercellular Signaling Peptides and Proteins; 50-81-7/Ascorbic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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