| Pharmacologic properties of proton pump inhibitors. | |
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MedLine Citation:
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PMID: 14587961 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Since their introduction into clinical practice in the 1980s, proton pump inhibitors (PPIs) have proved to be of enormous value in the management of acid peptic disorders. They have become the treatment of choice for most, if not all, acid-related gastrointestinal disorders, including gastroesophageal reflux disease, peptic ulcer, and Zollinger-Ellison syndrome. With approval of an intravenous formulation, the benefits of PPIs are extended to critically ill patients for whom oral drug administration is often unsuitable. Five PPIs are approved for clinical use in the United States. Although they share a common core structure and mechanism of action, it is important to understand the general pharmacology of these agents and how they differ from histamine2-receptor antagonists in order to optimize PPI therapy. |
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Authors:
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Lynda S Welage |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Pharmacotherapy Volume: 23 ISSN: 0277-0008 ISO Abbreviation: Pharmacotherapy Publication Date: 2003 Oct |
Date Detail:
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Created Date: 2003-10-31 Completed Date: 2004-02-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8111305 Medline TA: Pharmacotherapy Country: United States |
Other Details:
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Languages: eng Pagination: 74S-80S Citation Subset: IM |
Affiliation:
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Department of Clinical Sciences, University of Michigan College of Pharmacy, 428 Church Street, Ann Arbor, MI 48109, USA. lswelage@umich.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Anti-Ulcer Agents / pharmacokinetics, pharmacology*, therapeutic use Clinical Trials as Topic Drug Interactions Food-Drug Interactions Gastric Acid / secretion Humans Injections, Intravenous Peptic Ulcer / drug therapy*, physiopathology Proton Pumps / antagonists & inhibitors*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Anti-Ulcer Agents; 0/Proton Pumps |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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