Document Detail

Pharmacologic properties of proton pump inhibitors.
MedLine Citation:
PMID:  14587961     Owner:  NLM     Status:  MEDLINE    
Since their introduction into clinical practice in the 1980s, proton pump inhibitors (PPIs) have proved to be of enormous value in the management of acid peptic disorders. They have become the treatment of choice for most, if not all, acid-related gastrointestinal disorders, including gastroesophageal reflux disease, peptic ulcer, and Zollinger-Ellison syndrome. With approval of an intravenous formulation, the benefits of PPIs are extended to critically ill patients for whom oral drug administration is often unsuitable. Five PPIs are approved for clinical use in the United States. Although they share a common core structure and mechanism of action, it is important to understand the general pharmacology of these agents and how they differ from histamine2-receptor antagonists in order to optimize PPI therapy.
Lynda S Welage
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Pharmacotherapy     Volume:  23     ISSN:  0277-0008     ISO Abbreviation:  Pharmacotherapy     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-10-31     Completed Date:  2004-02-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8111305     Medline TA:  Pharmacotherapy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  74S-80S     Citation Subset:  IM    
Department of Clinical Sciences, University of Michigan College of Pharmacy, 428 Church Street, Ann Arbor, MI 48109, USA.
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MeSH Terms
Administration, Oral
Anti-Ulcer Agents / pharmacokinetics,  pharmacology*,  therapeutic use
Clinical Trials as Topic
Drug Interactions
Food-Drug Interactions
Gastric Acid / secretion
Injections, Intravenous
Peptic Ulcer / drug therapy*,  physiopathology
Proton Pumps / antagonists & inhibitors*,  metabolism
Reg. No./Substance:
0/Anti-Ulcer Agents; 0/Proton Pumps

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