| Pharmacologic profile of a low-molecular-weight heparin depolymerized by gamma-irradiation. | |
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MedLine Citation:
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PMID: 7660143 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Low molecular weight heparins (LMWHs) are considered to be the agent of choice for the prophylaxis of DVT in medical and surgical patients. Conventionally, these agents have been produced by fractionation of or by chemical or enzymatic depolymerization of native heparin. The fractionated heparin retains many of its biological properties such as AT III affinity and sulfate content gamma-irradiation (60Co) has been used to depolymerize GAGs (De Ambrosi et al. In: biomedical and Biotechnological Advances in Industrial Polysaccharides, pp. 45-53). This procedures has now been used for the preparation of LMWH derivatives of varying molecular weight. The current studies examine the biochemical and pharmacologic profile of one such gamma-irradiated depolymerized heparin. In standard clotting and amidolytic antiprotease assays (PT, APTT, AXa, Alla), gamma-irradiated depolymerized heparin produced equal or stronger activity when compared to a LMWH produced by nitrous acid depolymerization and retained the ability to active AT III and HCHII. Initial results indicate that LMWHs produced by gamma-irradiation exhibit comparable antithrombotic actions to those produced by chemical depolymerization when measured in animal models of thrombosis. gamma-Irradiation may be a useful method for the production of LMWHs. |
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Authors:
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W Jeske; O Iqbal; S Gonnela; G Boveri; G Torri; L De Ambrosi; J Fareed |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Seminars in thrombosis and hemostasis Volume: 21 ISSN: 0094-6176 ISO Abbreviation: Semin. Thromb. Hemost. Publication Date: 1995 |
Date Detail:
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Created Date: 1995-10-04 Completed Date: 1995-10-04 Revised Date: 2006-03-07 |
Medline Journal Info:
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Nlm Unique ID: 0431155 Medline TA: Semin Thromb Hemost Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 201-11 Citation Subset: IM |
Affiliation:
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Department of Pathology, Loyola, Univ. Med. Center, Maywood, IL 60153, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cobalt Radioisotopes Disease Models, Animal Gamma Rays Heparin, Low-Molecular-Weight / pharmacology*, radiation effects Nitrous Acid Polymers Rabbits Thrombosis / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Cobalt Radioisotopes; 0/Heparin, Low-Molecular-Weight; 0/Polymers; 7782-77-6/Nitrous Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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