Document Detail

Pharmacologic modulation of operative risk in patients who have cardiac disease.
MedLine Citation:
PMID:  16927934     Owner:  NLM     Status:  MEDLINE    
Cardiac complications continue to compose a major proportion of serious postoperative morbidity and mortality, and it is appropriate, therefore, that this area has received a lot of attention in the search for pharmacologic modulation of surgical outcomes. Despite numerous studies, conclusive data does not exist, making it difficult to recommend a course of action. beta-blockade has not only made it into national protocols, but is even considered as a quality assessment measure. However, the data are not quite as conclusive as it may sometimes appear. There have been few studies, with a small number of negative outcomes, and, at times, significant methodological concerns. The positive outcomes of meta-analyses rest essentially on a single trial in a highly selected patient population. Although use of beta-blockers in patients who have documented coronary artery disease and are undergoing major vascular procedures appears supported, it is premature to recommend beta-blockade for all patients with cardiac risk. Because these drugs are not without risks, it might be advisable to be restrained in their use until the results of the large-scale randomized POISE trial are available. For clonidine and statins, the data are even more tenuous, and largely based on retrospective reviews (with the exception of postprocedure use of statins, which is well supported). Here again, the results of large-scale prospective trials must become available before recommendations can be made. Finally, promising data indicate that it might be possible to modulate by pharmacologic means the neurocognitive decline that is frequently associated with cardiac surgery, and which is often considered by patients to be the most troublesome complication of the intervention.
Ashley M Shilling; Marcel E Durieux
Related Documents :
7667814 - Antithrombin iii concentrates--are they clinically useful?
16752934 - Adverse-event profile of crataegus spp.: a systematic review.
20575634 - Methylene blue for the treatment of septic shock.
18250104 - Long term efficacy of dots regimens for tuberculosis: systematic review.
12072634 - The changing paradigm for the treatment of colonic hemorrhage: superselective angiograp...
14736774 - A 12 week study comparing the fixed combination of latanoprost and timolol with the con...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Anesthesiology clinics     Volume:  24     ISSN:  1932-2275     ISO Abbreviation:  -     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-08-24     Completed Date:  2006-09-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101273663     Medline TA:  Anesthesiol Clin     Country:  United States    
Other Details:
Languages:  eng     Pagination:  365-79     Citation Subset:  IM    
Department of Anesthesia, University of Virginia Health System, Old Medical School, Room 4748, Charlottesville, VA 22908-0710, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cardiac Surgical Procedures* / mortality
Cognition Disorders / etiology,  prevention & control
Heart Diseases / drug therapy*,  mortality,  surgery
Intraoperative Complications / mortality,  prevention & control
Myocardial Ischemia / mortality,  prevention & control
Perioperative Care / methods
Postoperative Complications / mortality,  prevention & control*
Risk Factors
Surgical Procedures, Operative* / mortality

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Novel chemical mediators in the resolution of inflammation: resolvins and protectins.
Next Document:  Interactions of volatile anesthetics with neurodegenerative-disease-associated proteins.