Document Detail


[Pharmacologic measures for the prevention of mechanical ventilation-associated pneumonia].
MedLine Citation:
PMID:  20022067     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ventilator associated pneumonia is the principal infectious complication in the Intensive Care Unit (ICU), and represents the main infectious cause of morbidity and mortality. Its diagnosis and management is complex. Consequently, its prevention becomes a cornerstone in daily clinical practice. Daily interruption of sedation, oral and digestive decontamination, prophylactic administration of systemic and/or inhaled antibiotics, glycemic control, stress ulcer prophylaxis, transfusion policy and timing and adequacy of antibiotic treatment are the main suggested pharmacologic interventions. The aim of this review is to critically describe the principal pharmacologic interventions for the prevention of ventilator associated pneumonia, focusing on the degree of the evidence and the appropriateness for daily clinical practice.
Authors:
Marta Ulldemolins; Marcos I Restrepo; Jordi Rello
Publication Detail:
Type:  English Abstract; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2010-12-03
Journal Detail:
Title:  Medicina clínica     Volume:  136     ISSN:  0025-7753     ISO Abbreviation:  Med Clin (Barc)     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-18     Completed Date:  2011-04-21     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  0376377     Medline TA:  Med Clin (Barc)     Country:  Spain    
Other Details:
Languages:  spa     Pagination:  21-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2009 Elsevier España, S.L. All rights reserved.
Affiliation:
Servicio de Medicina Intensiva, Hospital Universitario de Tarragona Joan XXIII, Instituto de Investigación Sanitaria Pere Virgili (IISPV), Tarragona, Spain.
Vernacular Title:
Medidas farmacológicas para la prevención de la neumonía asociada a la ventilación mecánica.
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MeSH Terms
Descriptor/Qualifier:
Administration, Buccal
Administration, Inhalation
Anti-Bacterial Agents / administration & dosage*
Anti-Infective Agents, Local / administration & dosage*
Erythrocyte Transfusion / utilization
Gastrointestinal Tract / microbiology
Humans
Hypnotics and Sedatives / administration & dosage
Hypoglycemic Agents / administration & dosage
Injections, Intravenous
Mouth / microbiology
Pneumonia, Ventilator-Associated / prevention & control*
Stomach Ulcer / prevention & control
Time Factors
Grant Support
ID/Acronym/Agency:
KL2 RR025766/RR/NCRR NIH HHS; KL2 RR025766/RR/NCRR NIH HHS; KL2 TR000118/TR/NCATS NIH HHS; UL1 RR025767/RR/NCRR NIH HHS; UL1 TR000149/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Infective Agents, Local; 0/Hypnotics and Sedatives; 0/Hypoglycemic Agents

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