| Pharmacologic management of chronic rhinosinusitis, alone or with nasal polyposis. | |
| | |
MedLine Citation:
|
PMID: 15462715 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Patients with chronic rhinosinusitis (CRS) and chronic rhinosinusitis with nasal polyposis (CRSwNP) commonly present with nasal obstruction, nasal discharge, facial pressure/pain, and hyposmia of prolonged duration. Recent evidence suggests that, despite clinical similarities, CRS and CRSwNP are distinct entities with separate inflammatory pathways and cytokine profiles. Antibiotics and nasal steroids are the mainstay of treatment in CRS, whereas combination systemic and nasal steroids are the foundation of CRSwNP management. Allergy therapy may play a significant role in CRS, whereas antileukotriene therapy has demonstrated promise in CRSwNP. Although prolonged medical therapy is usually necessary with both disorders, surgery may also be required to relieve refractory symptoms, and to improve sinus aeration and nasal access for topical therapy. |
| | |
Authors:
|
M Boyd Gillespie; J David Osguthorpe |
Related Documents
:
|
8908465 - Cardiovascular adverse effects of antimicrobials in complex surgical cases. 16651075 - Antibiotics in trauma and orthopedic surgery -- a primer of evidence-based recommendati... 8646205 - Hematogenous osteomyelitis of the calcaneus in children: surgical treatment and use of ... 2874195 - Management of subdural intracranial empyemas should not always require surgery. 9534495 - The relationship between psychosocial variables and pain reporting in osteoarthritis of... 19427625 - Prospective randomized trial of paravertebral block for patients undergoing breast canc... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Current allergy and asthma reports Volume: 4 ISSN: 1529-7322 ISO Abbreviation: Curr Allergy Asthma Rep Publication Date: 2004 Nov |
Date Detail:
|
Created Date: 2004-10-06 Completed Date: 2005-01-04 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 101096440 Medline TA: Curr Allergy Asthma Rep Country: United States |
Other Details:
|
Languages: eng Pagination: 478-85 Citation Subset: IM |
Affiliation:
|
Department of Otolaryngology-Head and Neck Surgery, PO Box 250550, 135 Rutledge Avenue, Charleston, SC 29425, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Topical Adrenal Cortex Hormones / therapeutic use* Anti-Bacterial Agents / therapeutic use* Chronic Disease Comorbidity Drug Therapy, Combination Humans Inflammation Leukotriene Antagonists / therapeutic use* Nasal Obstruction Nasal Polyps / complications, drug therapy* Rhinitis / complications, drug therapy*, pathology Sinusitis / complications, drug therapy*, pathology |
| Chemical | |
Reg. No./Substance:
|
0/Adrenal Cortex Hormones; 0/Anti-Bacterial Agents; 0/Leukotriene Antagonists |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Treatment options for acute sinusitis in children.
Next Document: Surgical management of chronic rhinosinusitis and nasal polyposis: a review of the evidence.