Document Detail

Pharmacologic effect of thiphenamil HCl on lower urinary tract function of healthy asymptomatic volunteers.
MedLine Citation:
PMID:  1589919     Owner:  NLM     Status:  MEDLINE    
The effect of thiphenamil HCl on the urodynamic parameters of bladder filling, voiding and isometric contraction was examined in controls. Data were obtained from 25 control female subjects with a mean age of 27.6 +/- 6.6 years. Three urodynamic studies were done on each subject on 3 different days. These studies were: (1) control study, (2) drug study with a single oral dose of 400 mg thiphenamil HCl and (3) another with 800 mg. Each urodynamic study involved filling and voiding cystometrograms to characterize stability, sensations of fullness and urgency, bladder capacity, urethral opening pressure, maximum flow rate, maximum detrusor pressure and residual urine. In addition, isometric detrusor pressure measurements were made at bladder volume increments of 100 ml. Each urodynamic study was done in the sitting position using medium fill water cystometry at 20 ml/min. Isometric pressures were made by catheterizing the subject with an 18-french three-way Foley catheter with a 30-ml balloon. One lumen was used to fill the bladder and the second to measure pressure. The results show that bladder capacity and the volume at which sensations of fullness and urgency are expressed are not significantly changed under the influence of thiphenamil HCl. Significant differences were seen in the maximum pressure generated by the detrusor during voiding and in the maximum urine flow rate. These differences were most pronounced at the 800-mg thiphenamil HCl dose. The isometric data show a highly significant increase in the maximum isometric pressure developed at the low bladder volumes.(ABSTRACT TRUNCATED AT 250 WORDS)
C E Constantinou
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Urologia internationalis     Volume:  48     ISSN:  0042-1138     ISO Abbreviation:  Urol. Int.     Publication Date:  1992  
Date Detail:
Created Date:  1992-06-25     Completed Date:  1992-06-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0417373     Medline TA:  Urol Int     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  293-8     Citation Subset:  IM    
Division of Urology, Stanford University School of Medicine, Calif.
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MeSH Terms
Diphenylacetic Acids / administration & dosage,  pharmacology*
Dose-Response Relationship, Drug
Drug Evaluation
Parasympatholytics / administration & dosage,  pharmacology*
Sulfur Compounds
Urethra / drug effects*
Urinary Bladder / drug effects*
Urinary Bladder, Neurogenic / physiopathology
Urodynamics / drug effects*
Reg. No./Substance:
0/Diphenylacetic Acids; 0/Parasympatholytics; 0/Sulfur Compounds; 82-99-5/thiphenamil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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