Document Detail

Pharmacologic dilatation of the ductus arteriosus with prostaglandin E1 in infants with congenital heart disease.
MedLine Citation:
PMID:  81528     Owner:  NLM     Status:  MEDLINE    
Prostaglandin E1 (PGE1) has been used for successful palliation in nine infants with congenital heart disease. Seven patients had pulmonary atresia with ductal-dependent pulmonary blood flow. In this group, systemic O2 saturation increased from a mean value of 45% to 79% after infusion of PGE1, and surgical palliation was successfully done with the infants in stable condition, without hypoxemia or acidemia. An additional patient with coarctation of the aorta had marked ductal dilatation after PGE1 infusion as indicated by umbilical artery pulse pressure. The coarctation was repaired, with the infant in stable condition. The final patient had neonatal tricuspid insufficiency with right to left atrial shunting. Systemic O2 saturation was improved after PGE1 infusion, though the ductus was closed. The improved oxygenation was believed to be due to a reduction in pulmonary vascular resistance by PGE1. Prostaglandin E1 provides a powerful new tool for palliation of critical congenital heart disease in infants whose ductal constriction can markedly influence their clinical status.
T P Graham; G F Atwood; R J Boucek
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Southern medical journal     Volume:  71     ISSN:  0038-4348     ISO Abbreviation:  South. Med. J.     Publication Date:  1978 Oct 
Date Detail:
Created Date:  1978-12-29     Completed Date:  1978-12-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1238-41, 1246     Citation Subset:  AIM; IM    
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MeSH Terms
Ductus Arteriosus, Patent / physiopathology*
Heart Defects, Congenital / drug therapy*
Heart Septal Defects, Ventricular / drug therapy
Infant, Newborn
Oxygen / blood
Palliative Care
Partial Pressure
Prostaglandins E / pharmacology*,  therapeutic use
Pulmonary Artery / abnormalities
Transposition of Great Vessels / drug therapy
Reg. No./Substance:
0/Prostaglandins E; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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