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Pharmacologic agents for mucus clearance in bronchiectasis.
MedLine Citation:
PMID:  22640851     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
There are no approved pharmacologic agents to enhance mucus clearance in non-cystic fibrosis (CF) bronchiectasis. Evidence supports the use of hyperosmolar agents in CF, and studies with inhaled mannitol and hypertonic saline are ongoing in bronchiectasis. N-acetylcysteine may act more as an antioxidant than a mucolytic in other lung diseases. Dornase α is beneficial to patients with CF, but is not useful in patients with non-CF bronchiectasis. Mucokinetic agents such as β-agonists have the potential to improve mucociliary clearance in normals and many disease states, but have not been adequately studied in patients with bronchiectasis.
Authors:
Girish B Nair; Jonathan S Ilowite
Publication Detail:
Type:  Journal Article     Date:  2012-04-06
Journal Detail:
Title:  Clinics in chest medicine     Volume:  33     ISSN:  1557-8216     ISO Abbreviation:  Clin. Chest Med.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7907612     Medline TA:  Clin Chest Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  363-70     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Winthrop University Hospital, Mineola, NY, USA.
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