Document Detail

Pharmacologic agents in the management of hypertension--nisoldipine coat-core.
MedLine Citation:
PMID:  17396068     Owner:  NLM     Status:  MEDLINE    
Nisoldipine coat-core (CC), a 1,4-dihydropyridine calcium antagonist, is indicated for the treatment of hypertension and may be used alone or in combination with other antihypertensive agents. The CC technology allows for extended delivery of the drug and once-daily dosing. Nisoldipine CC tablets are absorbed across the entire gastrointestinal tract, including the colon. Eighty percent of the total dose is in the slow-release outer coat, while the core has immediate-release characteristics suitable for absorption in the distal gastrointestinal tract. Numerous double-blind, randomized studies of this agent have been done in patients with hypertension. The use of nisoldipine CC reduced both clinic and ambulatory blood pressure to a similar degree when compared with angiotensin-converting enzyme (ACE) inhibitors, beta-blockers, and the calcium antagonists amlodipine and felodipine. The drug has also been studied in hypertensive African Americans and demonstrated equivalent efficacy to amlodipine. Tolerability of the drug is good, with the most common side effect of edema at a rate similar to other dihydropyridine calcium antagonists. Thus, results of more than a decade of clinical trial data support the use of nisoldipine CC as once-daily therapy for the treatment of hypertension.
William B White
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of clinical hypertension (Greenwich, Conn.)     Volume:  9     ISSN:  1524-6175     ISO Abbreviation:  J Clin Hypertens (Greenwich)     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-30     Completed Date:  2007-08-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100888554     Medline TA:  J Clin Hypertens (Greenwich)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  259-66     Citation Subset:  IM    
Division Of Hypertension And Clinical Pharmacology, Pat And Jim Calhoun Cardiology Center, University Of Connecticut School of Medicine, Farmington, CT 06030-3940, USA.
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MeSH Terms
African Americans
African Continental Ancestry Group
Antihypertensive Agents / pharmacology*,  therapeutic use
Blood Pressure / drug effects
Calcium Channel Blockers / pharmacology*,  therapeutic use
Circadian Rhythm / drug effects
Dose-Response Relationship, Drug
Drug Interactions
Heart Rate / drug effects
Hypertension / drug therapy*,  ethnology,  physiopathology
Nisoldipine / pharmacology*,  therapeutic use
Randomized Controlled Trials as Topic
Reg. No./Substance:
0/Antihypertensive Agents; 0/Calcium Channel Blockers; 63675-72-9/Nisoldipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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