| Pharmacologic therapy for non ST-segment elevation acute coronary syndromes: focus on antithrombotic therapy. | |
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MedLine Citation:
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PMID: 20714797 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Antithrombotic therapy constitutes the basis of the management of acute coronary syndromes. It combines antiplatelet and anticoagulant therapy. Antiplatelet agents should combine aspirin and agents acting through the ADP pathway such as clopidogrel; newer antiplatelet agents such as prasugrel or ticagrelor have superior anti-ischemic efficacy, compared with clopidogrel. Intravenous glycoprotein IIb/IIIa inhibitors may be used in selected patients at high risk undergoing percutaneous coronary interventions. Unfractionated heparin constitutes the reference anticoagulant treatment. Enoxaparin provides slightly better anti-ischemic efficacy. Newer agents, such as bivalirudin or fondaparinux, reduce bleeding complications, with no improvement in anti-ischemic efficacy. The combination of antiplatelet and anticoagulant agents should be chosen according to the patients' characteristics and the management strategy of the acute coronary syndrome. |
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Authors:
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Nicolas Danchin; Nadia Aïssaoui |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy Volume: 24 ISSN: 1573-7241 ISO Abbreviation: Cardiovasc Drugs Ther Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-09-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8712220 Medline TA: Cardiovasc Drugs Ther Country: United States |
Other Details:
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Languages: eng Pagination: 325-30 Citation Subset: IM |
Affiliation:
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Hôpital Européen Georges Pompidou, Paris, Université de Paris René Descartes, Paris, France. nicolas.danchin@egp.aphp.fr |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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