Document Detail


Pharmacologic management of chronic reno-cardiac syndrome.
MedLine Citation:
PMID:  23143732     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chronic kidney disease (CKD) significantly increases cardiovascular morbidity and mortality. CKD remains an under-represented population in cardiovascular clinical trials, and cardiovascular disease is an under-treated entity in CKD. Traditional cardiovascular risk factors in conjunction with uremia-related complications often progress to myocardial dysfunction. Such uremic cardiomyopathy leads to over-activation of neurohormonal pathways with detrimental effects. Management of the reno-cardiac syndrome (RCS) requires the targeting of these multiple facets. In this article we discuss the relevant pathophysiology of RCS, and present the clinical data related to its management.
Authors:
Nael Hawwa; Martin J Schreiber; W H Wilson Tang
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current heart failure reports     Volume:  10     ISSN:  1546-9549     ISO Abbreviation:  Curr Heart Fail Rep     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-08     Completed Date:  2013-07-10     Revised Date:  2014-03-07    
Medline Journal Info:
Nlm Unique ID:  101196487     Medline TA:  Curr Heart Fail Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  54-62     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cardio-Renal Syndrome / drug therapy*,  etiology,  physiopathology
Cardiovascular Agents / therapeutic use*
Chronic Disease
Humans
Renal Replacement Therapy / methods
Renin-Angiotensin System / physiology
Risk Factors
Grant Support
ID/Acronym/Agency:
P20 HL113452/HL/NHLBI NIH HHS; R01 HL103931/HL/NHLBI NIH HHS; U10 HL110336/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Cardiovascular Agents
Comments/Corrections

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