| Pharmacokinetics of a valpromide isomer, valnoctamide, in healthy subjects. | |
| | |
MedLine Citation:
|
PMID: 2111246 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The pharmacokinetics of a single 400 mg oral dose of valnoctamide (VCD) has been investigated in seven healthy, adult, male volunteers. VCD was not biotransformed rapidly to its corresponding acid valnoctic acid (VCA), unlike its isomer valpromide (VPD). It had a mean residence time of 13.2 h and a terminal half-life of 9.3 h. Throughout the study, only low plasma levels of VCA could be detected. Thus, unlike VPD, which is a pro-drug of the corresponding acid, (valproic acid, VPA). VCD appears to act as a drug in its own right, and it does not undergo similar hydrolysis. The pharmacokinetic difference may account for the different pharmacological activities of the two isomers. |
| | |
Authors:
|
M Bialer; A Haj-Yehia; N Barzaghi; F Pisani; E Perucca |
Related Documents
:
|
6798056 - Valproic acid and several metabolites: quantitative determination in serum, urine, brea... 848726 - Laryngeal oedema due to hereditary angioedema. 6419536 - Treatment of epileptic patients with valproic acid does not modify plasma and urine sho... 9572536 - Aminocaproic acid and tranexamic acid increase the rate of acute corneal reepithelializ... 10763586 - Isolation and chemical analysis of a fatty acid fraction of kalanchoe pinnata with a po... 6786336 - Quantitative solid-phase edman degradation for evaluation of extended solid-phase pepti... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: European journal of clinical pharmacology Volume: 38 ISSN: 0031-6970 ISO Abbreviation: Eur. J. Clin. Pharmacol. Publication Date: 1990 |
Date Detail:
|
Created Date: 1990-06-27 Completed Date: 1990-06-27 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 1256165 Medline TA: Eur J Clin Pharmacol Country: GERMANY, WEST |
Other Details:
|
Languages: eng Pagination: 289-91 Citation Subset: IM |
Affiliation:
|
Department of Pharmacy, School of Pharmacy, Hebrew University, Jerusalem, Israel. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Amides / pharmacokinetics* Half-Life Humans Isomerism Male Valproic Acid / analogs & derivatives, pharmacokinetics* |
| Chemical | |
Reg. No./Substance:
|
0/Amides; 2430-27-5/dipropylacetamide; 4171-13-5/valnoctamide; 99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Altered flecainide disposition in healthy volunteers taking quinine.
Next Document: Effects of Ca2+ entry blockers on CaCl2-, KCl- and noradrenaline-induced contractions of goat cerebr...