Document Detail


Pharmacokinetics of a valpromide isomer, valnoctamide, in healthy subjects.
MedLine Citation:
PMID:  2111246     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pharmacokinetics of a single 400 mg oral dose of valnoctamide (VCD) has been investigated in seven healthy, adult, male volunteers. VCD was not biotransformed rapidly to its corresponding acid valnoctic acid (VCA), unlike its isomer valpromide (VPD). It had a mean residence time of 13.2 h and a terminal half-life of 9.3 h. Throughout the study, only low plasma levels of VCA could be detected. Thus, unlike VPD, which is a pro-drug of the corresponding acid, (valproic acid, VPA). VCD appears to act as a drug in its own right, and it does not undergo similar hydrolysis. The pharmacokinetic difference may account for the different pharmacological activities of the two isomers.
Authors:
M Bialer; A Haj-Yehia; N Barzaghi; F Pisani; E Perucca
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  38     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1990  
Date Detail:
Created Date:  1990-06-27     Completed Date:  1990-06-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  289-91     Citation Subset:  IM    
Affiliation:
Department of Pharmacy, School of Pharmacy, Hebrew University, Jerusalem, Israel.
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MeSH Terms
Descriptor/Qualifier:
Adult
Amides / pharmacokinetics*
Half-Life
Humans
Isomerism
Male
Valproic Acid / analogs & derivatives,  pharmacokinetics*
Chemical
Reg. No./Substance:
0/Amides; 2430-27-5/dipropylacetamide; 4171-13-5/valnoctamide; 99-66-1/Valproic Acid

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