| Pharmacokinetics of valerenic acid after administration of valerian in healthy subjects. | |
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MedLine Citation:
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PMID: 16220575 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To describe the pharmacokinetics of valerenic acid in a group of healthy adults after a single oral dose of valerian using a newly developed sensitive assay for serum concentrations of valerenic acid, a commonly used marker for qualitative and quantitative analysis of valerian root and valerian products. STUDY DESIGN: Six healthy adults (22-61 years, five men, one female) received a single 600 mg dose of valerian at 08:00. Blood samples were collected for 8 h after administration. Valerenic acid was extracted from serum and measured using a LC/MS/MS method developed in our laboratory. RESULTS: The maximum serum concentration of valerenic acid for five of the six subjects occurred between 1 and 2 h ranging from 0.9 to 2.3 ng/mL. Valerenic acid serum concentrations were measurable for at least 5 h after the valerian dose. One subject showed a peak plasma value at 1 h and a second peak at 5 h. The elimination half-life (T(1/2)) for valerenic acid was 1.1 +/- 0.6 h. The area under the concentration time curve (AUC) as a measure of valerenic acid exposure was variable (4.80 +/- 2.96 microg/mL. h) and not correlated with subject's age or weight. CONCLUSIONS: Assuming that valerenic acid serum concentrations correlate with the pharmacological activity of valerian, the timing of the valerenic acid peak concentration is consistent with the standard dosage recommendation to take valerian 30 min to 2 h before bedtime. Ongoing studies are evaluating the relationship between valerenic acid serum concentrations and objective measures of sleep in patients. |
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Authors:
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Gail D Anderson; Gary W Elmer; Eric D Kantor; Ian E Templeton; Michael V Vitiello |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Phytotherapy research : PTR Volume: 19 ISSN: 0951-418X ISO Abbreviation: Phytother Res Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-10-18 Completed Date: 2006-01-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: England |
Other Details:
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Languages: eng Pagination: 801-3 Citation Subset: IM |
Copyright Information:
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Copyright 2005 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Pharmacy, University of Washington, Seattle, 98195, USA. gaila@u.washington.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Area Under Curve Female Humans Hypnotics and Sedatives / administration & dosage, blood, pharmacokinetics* Indenes / administration & dosage, blood, pharmacokinetics* Male Middle Aged Phytotherapy* Sesquiterpenes / administration & dosage, blood, pharmacokinetics* Valerian* |
| Grant Support | |
ID/Acronym/Agency:
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K02-MH01158/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hypnotics and Sedatives; 0/Indenes; 0/Sesquiterpenes; 3569-10-6/valerenic acid |
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