Document Detail


Pharmacokinetics of valerenic acid after administration of valerian in healthy subjects.
MedLine Citation:
PMID:  16220575     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To describe the pharmacokinetics of valerenic acid in a group of healthy adults after a single oral dose of valerian using a newly developed sensitive assay for serum concentrations of valerenic acid, a commonly used marker for qualitative and quantitative analysis of valerian root and valerian products. STUDY DESIGN: Six healthy adults (22-61 years, five men, one female) received a single 600 mg dose of valerian at 08:00. Blood samples were collected for 8 h after administration. Valerenic acid was extracted from serum and measured using a LC/MS/MS method developed in our laboratory. RESULTS: The maximum serum concentration of valerenic acid for five of the six subjects occurred between 1 and 2 h ranging from 0.9 to 2.3 ng/mL. Valerenic acid serum concentrations were measurable for at least 5 h after the valerian dose. One subject showed a peak plasma value at 1 h and a second peak at 5 h. The elimination half-life (T(1/2)) for valerenic acid was 1.1 +/- 0.6 h. The area under the concentration time curve (AUC) as a measure of valerenic acid exposure was variable (4.80 +/- 2.96 microg/mL. h) and not correlated with subject's age or weight. CONCLUSIONS: Assuming that valerenic acid serum concentrations correlate with the pharmacological activity of valerian, the timing of the valerenic acid peak concentration is consistent with the standard dosage recommendation to take valerian 30 min to 2 h before bedtime. Ongoing studies are evaluating the relationship between valerenic acid serum concentrations and objective measures of sleep in patients.
Authors:
Gail D Anderson; Gary W Elmer; Eric D Kantor; Ian E Templeton; Michael V Vitiello
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  19     ISSN:  0951-418X     ISO Abbreviation:  Phytother Res     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-10-18     Completed Date:  2006-01-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  801-3     Citation Subset:  IM    
Copyright Information:
Copyright 2005 John Wiley & Sons, Ltd.
Affiliation:
Department of Pharmacy, University of Washington, Seattle, 98195, USA. gaila@u.washington.edu
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Area Under Curve
Female
Humans
Hypnotics and Sedatives / administration & dosage,  blood,  pharmacokinetics*
Indenes / administration & dosage,  blood,  pharmacokinetics*
Male
Middle Aged
Phytotherapy*
Sesquiterpenes / administration & dosage,  blood,  pharmacokinetics*
Valerian*
Grant Support
ID/Acronym/Agency:
K02-MH01158/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Hypnotics and Sedatives; 0/Indenes; 0/Sesquiterpenes; 3569-10-6/valerenic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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