| Pharmacokinetics of valaciclovir. | |
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MedLine Citation:
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PMID: 15140857 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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While active against Herpesviridae, oral aciclovir is limited by low and inconsistent bioavailability. Modification of aciclovir by valine esterification, producing valaciclovir, results in significant increases in systemic aciclovir plasma levels. The exact mechanism of increased absorption with valaciclovir is not fully determined but probably involves intestinal dipeptide transporters, followed by rapid ester hydrolysis in the small intestine and liver. The enhanced pharmacokinetics of valaciclovir have translated into improvements in clinical efficacy and patient convenience. |
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Authors:
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Conan MacDougall; B Joseph Guglielmo |
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Publication Detail:
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Type: Journal Article; Review Date: 2004-05-12 |
Journal Detail:
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Title: The Journal of antimicrobial chemotherapy Volume: 53 ISSN: 0305-7453 ISO Abbreviation: J. Antimicrob. Chemother. Publication Date: 2004 Jun |
Date Detail:
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Created Date: 2004-05-28 Completed Date: 2004-08-20 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7513617 Medline TA: J Antimicrob Chemother Country: England |
Other Details:
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Languages: eng Pagination: 899-901 Citation Subset: IM |
Affiliation:
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Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, CA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acyclovir
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analogs & derivatives*,
pharmacokinetics* Animals Antiviral Agents / pharmacokinetics* Biotransformation Carrier Proteins / metabolism Humans Hydrolysis Symporters* Valine / analogs & derivatives*, pharmacokinetics* |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/Carrier Proteins; 0/PepT1 protein; 0/SLC15A1 protein, human; 0/Symporters; 124832-27-5/valacyclovir; 59277-89-3/Acyclovir; 7004-03-7/Valine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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