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Pharmacokinetics of toxic chemicals in breast milk: use of PBPK models to predict infant exposure.
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MedLine Citation:
PMID:  12055064     Owner:  NLM     Status:  MEDLINE    
Factors controlling the transfer of potentially toxic chemicals in the breast milk of nursing mothers include both chemical characteristics, such as lipophilicity, and physiologic changes during lactation. Physiologically based pharmacokinetic (PBPK) models can aid in the prediction of infant exposure via breast milk. Benefits of these quantitative models include the ability to account for changing maternal physiology and transfer kinetics, as well as the chemical-specific characteristics, in order to produce more accurate estimates of neonatal risk. A recently developed PBPK model for perchlorate and iodide kinetics in the lactating and neonatal rat demonstrates the utility of PBPK modeling in predicting maternal and neonatal distribution of these two compounds. This model incorporates time-dependent changes in physiologic characteristics and includes interactions between iodide and perchlorate that alter the distribution and kinetics of iodide.
Rebecca A Clewell; Jeffery M Gearhart
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Environmental health perspectives     Volume:  110     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-10     Completed Date:  2002-07-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  United States    
Other Details:
Languages:  eng     Pagination:  A333-7     Citation Subset:  IM    
Geo-Centers, Inc., Wright-Patterson Air Force Base, Ohio 45433, USA.
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MeSH Terms
Breast Feeding
Chemistry, Physical
Environmental Pollutants / pharmacokinetics*,  toxicity*
Infant, Newborn
Iodides / pharmacokinetics
Milk, Human / chemistry*
Models, Chemical*
Perchloric Acid / pharmacokinetics
Physicochemical Phenomena
Risk Assessment
Sodium Compounds / pharmacokinetics
Reg. No./Substance:
0/Environmental Pollutants; 0/Iodides; 0/Sodium Compounds; 7601-89-0/sodium perchlorate; 7601-90-3/Perchloric Acid
Comment In:
Environ Health Perspect. 2002 Nov;110(11):A663; author reply A663-4   [PMID:  12440394 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 6 Year: 2002
Volume: 110 Issue: 6
First Page: A333 Last Page: A337
ID: 1240887
PubMed Id: 12055064
Publisher Item Identifier: sc271_5_1835

Pharmacokinetics of toxic chemicals in breast milk: use of PBPK models to predict infant exposure.
Rebecca A Clewell
Jeffery M Gearhart
Geo-Centers, Inc., Wright-Patterson Air Force Base, Ohio 45433, USA.

Article Categories:
  • Research Article

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