Document Detail


Pharmacokinetics of topiramate during pregnancy.
MedLine Citation:
PMID:  19740626     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To study the effects of pregnancy on plasma concentrations of topiramate (TPM).
METHODS: An established routine fluorescence polarization immunoassay (FPIA) method was used to determine TPM concentrations in 15 women with epilepsy treated with TPM during altogether 17 pregnancies.
RESULTS: In 10 pregnancies, where samples were available from all three trimesters, the mean TPM dose/concentration ratio (D/C-ratio) was significantly higher than outside pregnancy baseline value 37.3 L/day (+/-15.9), during the 2nd, 67.5L/day (+/-23.4), and the 3rd trimester, 65.1L/day (+/-30.4), but not during the 1st, 49.4 L/day (+/-29.4). Including seven additional pregnancies enrolled late with data only from the 3rd trimester, the mean D/C-ratio during the 3rd trimester was 67.4 L/day (+/-27.5) compared to baseline, 38.8L/day (+/-18.0), an average increase by 71.8%. There was a pronounced intra-individual variability in alterations in D/C-ratios during pregnancies.
CONCLUSIONS: Our data show a significant pregnancy-related increase in D/C-ratios of TPM suggesting that therapeutic drug monitoring might be of value.
Authors:
Inger Ohman; Anne Sabers; Pierre de Flon; Gerhard Luef; Torbjörn Tomson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-08
Journal Detail:
Title:  Epilepsy research     Volume:  87     ISSN:  1872-6844     ISO Abbreviation:  Epilepsy Res.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-25     Completed Date:  2010-02-18     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  8703089     Medline TA:  Epilepsy Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  124-9     Citation Subset:  IM    
Affiliation:
Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden. inger.ohman@ki.se
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MeSH Terms
Descriptor/Qualifier:
Adult
Analysis of Variance
Anticonvulsants / pharmacokinetics
Dose-Response Relationship, Drug
Drug Monitoring
Epilepsy / drug therapy*
Female
Fluorescence Polarization Immunoassay
Fructose / analogs & derivatives*,  pharmacokinetics
Humans
Pregnancy
Pregnancy Trimester, Third
Chemical
Reg. No./Substance:
0/Anticonvulsants; 0H73WJJ391/topiramate; 30237-26-4/Fructose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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