| Pharmacokinetics of topically applied ciprofloxacin in equine tears. | |
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MedLine Citation:
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PMID: 17970994 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the pharmacokinetics of topically applied ciprofloxacin 0.3% ophthalmic solution in tears of healthy horses. ANIMAL STUDIED: Twenty healthy, adult, mixed-breed horses. PROCEDURES: Twenty study horses were confirmed free of ophthalmic disease by complete ophthalmic examination. Seventy microliters of 0.3% ciprofloxacin (Ciloxan) was placed in the ventral cul-de-sac of each eye using a microliter syringe and 19-g cannula. Population kinetics were carried out by sampling the tear film from the lower cul-de-sac of each eye with tear test strips at 5, 10, 15 and 30 min and 1, 2, 4 and 6 h post administration for a total of five samples at each time-point. Sample collection time was 15 s. Concentrations of ciprofloxacin were determined using high performance liquid chromatography. RESULTS: Mean (+/-SD) of the Schirmer tear test results from all eyes was 23.4 +/- 4.8 mm wetting in 1 min. Mean concentration of ciprofloxacin in the tears at 5 min post administration was 498.4 +/- 266.8 microg/g. Mean concentration rapidly declined and began to plateau at 30 min. The mean tear concentrations of ciprofloxacin at 30 min and at 1, 2, 4 and 6 h were 66.6 +/- 56.0, 60.25 +/- 55.7, 42.25 +/- 30.9, 36.25 +/- 32.0, and 45.5 +/- 46.5 microg/g, respectively. CONCLUSIONS: The pharmacokinetics of ciprofloxacin in normal horses are similar to those in rabbits and humans. Topical application of ciprofloxacin resulted in a mean tear concentration of ciprofloxacin that remained above the MIC(90) levels for most pathogenic bacteria for 6 h post administration. |
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Authors:
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Diane V H Hendrix; Jamie L Stuffle; Sherry K Cox |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Veterinary ophthalmology Volume: 10 ISSN: 1463-5216 ISO Abbreviation: Vet Ophthalmol Publication Date: 2007 Nov-Dec |
Date Detail:
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Created Date: 2007-10-31 Completed Date: 2007-12-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100887377 Medline TA: Vet Ophthalmol Country: England |
Other Details:
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Languages: eng Pagination: 344-7 Citation Subset: IM |
Affiliation:
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Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996-4544, USA. dhendrix@utk.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Infective Agents / administration & dosage, pharmacokinetics* Chromatography, High Pressure Liquid / veterinary Ciprofloxacin / administration & dosage, pharmacokinetics* Horses / metabolism* Ophthalmic Solutions / administration & dosage, pharmacokinetics* Reproducibility of Results Tears / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents; 0/Ophthalmic Solutions; 85721-33-1/Ciprofloxacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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