| Pharmacokinetics of tolfenamic acid and its detection time in urine after intravenous administration of the drug in camels (Camelus dromedarius). | |
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MedLine Citation:
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PMID: 9829406 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To document tolfenamic acid disposition variables, identify its major phase-1 metabolite and fragmentation pattern, and establish detection time in urine after single IV bolus administration to make recommendations on avoiding violative residues in racing camels. ANIMALS: 7 healthy camels (6 males, 1 female), 8 to 11 years old and weighing from 300 to 480 kg. PROCEDURE: Blood samples were collected at 0, 5, 10, 15, 30, 45, and 60 minutes and at 1.5, 2, 2.5, 3, 3.5, 4, 5, 6, 8, 12, 13, 14, 15, and 16 hours after IV administration of tolfenamic acid (2.0 mg/kg of body weight). Urine samples were collected daily for 14 days after drug administration. Serum tolfenamic acid concentration was measured; limit of quantification was 50 ng/ml. A metabolite of tolfenamic acid in urine was isolated and identified, and its major fragmentation pattern was verified. Screening for tolfenamic acid and its metabolite in urine was performed. RESULTS: Mean +/- SEM tolfenamic acid elimination half-life was 5.76+/-0.26 hours. Total body clearance was 0.109+/-0.011 L/kg/h, and steady-state volume of distribution was 0.68+/-0.06 L/kg. Detection time for tolfenamic acid and its hydroxylated metabolite in urine after IV administration of a dose of 2.0 mg/kg was 5 and 7 days, respectively. CONCLUSIONS: Camels eliminate tolfenamic acid mainly via metabolism more slowly than do cattle. The extrapolated dose regimen from cattle to camels appears inappropriate. Veterinarians are advised not to use tolfenamic acid in camels for at least 8 days prior to racing. |
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Authors:
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I A Wasfi; M ElGhazali; A A Hadi; O Zorob; N S Boni; N A Alkatheeri; I M Barezaiq |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of veterinary research Volume: 59 ISSN: 0002-9645 ISO Abbreviation: Am. J. Vet. Res. Publication Date: 1998 Nov |
Date Detail:
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Created Date: 1999-01-25 Completed Date: 1999-01-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375011 Medline TA: Am J Vet Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1451-8 Citation Subset: IM |
Affiliation:
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Camelracing Forensic Laboratory, Forensic Science Laboratory, Abu Dhabi, United Arab Emirates. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anthranilic Acids / administration & dosage, pharmacokinetics*, urine Anti-Inflammatory Agents, Non-Steroidal / administration & dosage, pharmacokinetics*, urine Camels / metabolism* Chromatography, High Pressure Liquid / veterinary Chromatography, Thin Layer / veterinary Drug Evaluation / veterinary Female Half-Life Injections, Intravenous / veterinary Male Mass Spectrometry / veterinary Metabolic Clearance Rate Models, Chemical |
| Chemical | |
Reg. No./Substance:
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0/Anthranilic Acids; 0/Anti-Inflammatory Agents, Non-Steroidal; 13710-19-5/tolfenamic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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