Document Detail


Pharmacokinetics and tolerance of sertaconazole in man after repeated percutaneous administration.
MedLine Citation:
PMID:  1627199     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The local and systemic tolerance of 7-chloro-3-[1-(2,4-dichlorophenyl)-2-(1H- imidazol-1-yl)ethoxy-methyl]benzo[b]thiophene (sertaconazole, FI-7045, CAS 99592-32-2) 2% cream was studied in healthy volunteers after cutaneous application in an increasing-dose schedule during 13 days. Blood and urine samples were collected after the application of 16 g of cream. Percentage of absorption was determined in eight 3 x 3 cm areas of the volar arm skin after 2 mg cream topical application. No changes on vital signs (blood pressure, heart rate and body temperature) or in the ECG were found during the trial. Sertaconazole did not produce skin irritation nor systemic side effects. Sertaconazole was not detected in either the serum and urine samples obtained. The percentage of cutaneous absorption at 24 h after administration reached 72% of the applied dose.
Authors:
M Farré; B Ugena; J M Badenas; M Márquez; P Roset; J A Ortiz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  42     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-08-12     Completed Date:  1992-08-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  752-4     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Toxicology, Institut Municipal d'Investigació Mèdica, Barcelona, Spain.
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Adolescent
Adult
Antifungal Agents / administration & dosage,  adverse effects,  pharmacokinetics*
Body Temperature / drug effects
Drug Tolerance
Hemodynamics / drug effects
Humans
Imidazoles / administration & dosage,  adverse effects,  pharmacokinetics*
Injections, Subcutaneous
Irritants
Male
Skin Absorption
Thiophenes / administration & dosage,  adverse effects,  pharmacokinetics*
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Imidazoles; 0/Irritants; 0/Thiophenes; 99592-32-2/sertaconazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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