| Pharmacokinetics and tissue localization of antisense oligonucleotides in balloon-injured pig coronary arteries after local delivery with an iontophoretic balloon catheter. | |
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MedLine Citation:
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PMID: 9213036 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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When delivered locally to the arterial wall by passive fluid transfer systems such as perforated balloons, water-soluble compounds in aqueous solution are not readily taken up by tissue, show low levels of cellular localization, and are quickly lost by wash-out. One approach to improve delivery is addition of an "active" component to the catheter system to change the nature of the drug-to-tissue interaction. Using an iontophoretic balloon catheter to deliver antisense oligonucleotide (ODN) to pig coronary arteries after balloon angioplasty, we determined the quantity and localization of ODN in the tissue. By radiolabeling, 7.3 +/- 2.4 micrograms ODN was present at 30 min, 1.5 +/- 0.6 at 2 h, 0.52 +/- 0.35 at 24 h, and 0.26 +/- 0.11 at 7 d. By fluorescent labeling, circumferential medial uptake and adventitial delivery at the site of medial injury was observed, with primarily cellular localization. The iontophoretic catheter thus appears to be a useful device for ODN delivery to arterial tissue. |
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Authors:
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K A Robinson; N A Chronos; E Schieffer; S J Palmer; G D Cipolla; P G Milner; R G Walsh; S B King |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Catheterization and cardiovascular diagnosis Volume: 41 ISSN: 0098-6569 ISO Abbreviation: Cathet Cardiovasc Diagn Publication Date: 1997 Jul |
Date Detail:
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Created Date: 1997-08-21 Completed Date: 1997-08-21 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7508512 Medline TA: Cathet Cardiovasc Diagn Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 354-9 Citation Subset: IM |
Affiliation:
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Andreas Gruentzig Cardiovascular Center, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA. keith_robinson@email.eusch.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Transluminal, Percutaneous Coronary
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instrumentation* Animals Coronary Vessels / drug effects, injuries*, pathology Drug Delivery Systems / instrumentation* Female Gene Therapy Iontophoresis / instrumentation* Microscopy, Fluorescence Oligonucleotides, Antisense / administration & dosage, pharmacokinetics* Stents Swine Tunica Media / drug effects, injuries, pathology |
| Chemical | |
Reg. No./Substance:
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0/Oligonucleotides, Antisense |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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