| Pharmacokinetics and tissue distribution of 14C-labeled grape polyphenols in the periphery and the central nervous system following oral administration. | |
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MedLine Citation:
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PMID: 20673061 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Grape polyphenols confer potential health benefits, including prevention of neurodegenerative diseases. To determine the absorption and tissue distribution of the complex grape polyphenol mixture, (14)C-labeled polyphenols were biosynthesized by grape cell suspension cultures, during co-incubation with radioisotopically labeled sucrose, and fractionated into polyphenolic subfractions. The pharmacokinetics and distribution of grape polyphenols into blood, brain, and peripheral interstitial fluid were determined by tracking the (14)C label. The blood peak (14)C concentration of the fractions ranged from 15 minutes to 4 hours. Absorption and tissue distribution varied greatly between fractions. Concentrations in interstitial fluid were lower than in blood. The amount of residual label in the brain at 24 hours ranged from 0.1% to 1.7% of the dose, depending on the fraction. (14)C label found in the brain tissue and brain microdialysate indicated that grape polyphenols or their metabolites are able to cross the blood-brain barrier. Using (14)C-labeled plant polyphenols it is possible to track the compounds or their metabolic products into any tissue and determine distribution patterns in spite of low concentrations. A central question regarding the potential role of dietary polyphenolics in neurodegenerative research is whether they are bioavailable in the brain. Our observations indicate that some grape-derived polyphenolics do reach the brain, which suggests their potential value for applications in neurodegenerative disorders. |
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Authors:
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Elsa M Janle; Mary Ann Lila; Michael Grannan; Lauren Wood; Aine Higgins; Gad G Yousef; Randy B Rogers; Helen Kim; George S Jackson; Lap Ho; Connie M Weaver |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of medicinal food Volume: 13 ISSN: 1557-7600 ISO Abbreviation: J Med Food Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-02 Completed Date: 2010-12-06 Revised Date: 2011-08-03 |
Medline Journal Info:
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Nlm Unique ID: 9812512 Medline TA: J Med Food Country: United States |
Other Details:
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Languages: eng Pagination: 926-33 Citation Subset: IM |
Affiliation:
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Department of Foods and Nutrition, Purdue University, West Lafayette, Indiana 47907-2059, USA. janle@purdue.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Alzheimer Disease / drug therapy, metabolism Animals Carbon Radioisotopes / analysis, pharmacokinetics Central Nervous System / chemistry, drug effects, metabolism* Disease Models, Animal Extracellular Fluid / chemistry, drug effects, metabolism* Flavonoids / administration & dosage, chemistry, pharmacokinetics* Humans Male Phenols / administration & dosage, chemistry, pharmacokinetics* Plant Extracts / administration & dosage, chemistry, pharmacokinetics* Rats Rats, Sprague-Dawley Tissue Distribution Vitis / chemistry* |
| Grant Support | |
ID/Acronym/Agency:
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P50 AT 00477/AT/NCCAM NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Carbon Radioisotopes; 0/Flavonoids; 0/Phenols; 0/Plant Extracts; 0/polyphenols |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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