| Pharmacokinetics of theophylline in infancy. | |
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MedLine Citation:
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PMID: 711929 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Theophylline clearance rates and half-life values were measured in 15 infants aged three to 23 months, after infusion of aminophylline by the intravenous route for at least 24 hours. The mean clearance rate was 1.07 +/- 0.55 ml/min-kg, which is comparable with values obtained by others in older children. There was some correlation of clearance rates with age. The mean half-life was 4.4 +/- 2.2 hours. There was a tenfold variability in half-life, suggesting that individualization of theophylline dose is especially important in infants if undertreatment and toxicity are to be avoided. |
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Authors:
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F E Simons; K J Simons |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical pharmacology Volume: 18 ISSN: 0091-2700 ISO Abbreviation: J Clin Pharmacol Publication Date: 1978 Oct |
Date Detail:
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Created Date: 1979-01-15 Completed Date: 1979-01-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0366372 Medline TA: J Clin Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 472-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aminophylline / metabolism Half-Life Humans Infant Kinetics Theophylline / blood, metabolism* |
| Chemical | |
Reg. No./Substance:
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317-34-0/Aminophylline; 58-55-9/Theophylline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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