Document Detail

Pharmacokinetics of theophylline in children with asthma.
MedLine Citation:
PMID:  972795     Owner:  NLM     Status:  MEDLINE    
The pharmacokinetics of theophylline following intravenous injection of aminophylline, 4 mg/kg of body weight, were determined in 30 children with asthma and in 6 normal adult volunteers. The average total clearance of theophylline was 87 ml/hr/kg in the children and 57 ml/hr/kg in the adults. The biologic half-life of theophylline in the children ranged from 1.42 to 7.85 hours, reflecting mainly pronounced interindividual differences in the elimination rate constant of the drug. There was no significant difference between the children and adults with respect to the distribution rate constants and apparent volumes of distribution of theophylline, but the elimination rate constant of the drug was considerably higher in children than in adults. Thus, children eliminate theophylline more rapidly on the average than do adults and also show pronounced interindividual differences in the elimination of the drug. Compared to adults, children tend to require relatively larger amounts of theophylline per day and the doses may have to be given at shorter intervals of time.
E F Ellis; R Koysooko; G Levy
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatrics     Volume:  58     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1976 Oct 
Date Detail:
Created Date:  1976-12-03     Completed Date:  1976-12-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  542-7     Citation Subset:  AIM; IM    
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MeSH Terms
Age Factors
Aminophylline / administration & dosage,  metabolism*,  therapeutic use
Asthma / drug therapy*
Injections, Intravenous
Metabolic Clearance Rate
Reg. No./Substance:

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