| Pharmacokinetics of terbutaline during pregnancy. | |
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MedLine Citation:
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PMID: 3956566 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Terbutaline in plasma was determined in three groups of women by gas chromatography-mass spectrometry. Eight women received a single i.v. dose of 0.25 mg terbutaline sulphate during pregnancy and 3-6 months after delivery. Mean plasma clearance was 29% higher during pregnancy than after delivery. There was a subsequent decrease in mean terminal half-life from 5.3 to 3.7 h and in mean residence time from 5.3 to 3.4 h. There was no change in volume of distribution. A second group of pregnant women in premature labour (n = 8) received oral terbutaline 5 mg t.d.s. The dosing was repeated after delivery. The mean steady state plasma concentration of terbutaline was about 30% lower during pregnancy than after delivery. A third group of women in preterm labour (n = 8) was treated with an i.v. infusion of terbutaline. The concentrations of terbutaline found on cessation of uterine contractions ranged between 12.8 and 31.5 ng/ml. At present there is no basis for formulation of a "therapeutic plasma level" of terbutaline for the treatment of preterm labour. |
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Authors:
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S Lyrenäs; A Grahnén; B Lindberg; B Lindström; G Lönnerholm |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of clinical pharmacology Volume: 29 ISSN: 0031-6970 ISO Abbreviation: Eur. J. Clin. Pharmacol. Publication Date: 1986 |
Date Detail:
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Created Date: 1986-04-29 Completed Date: 1986-04-29 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 1256165 Medline TA: Eur J Clin Pharmacol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 619-23 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Female Fetal Heart / drug effects Half-Life Heart Rate / drug effects Humans Injections, Intravenous Kinetics Obstetric Labor, Premature / prevention & control Pregnancy Terbutaline / administration & dosage, adverse effects, metabolism* Uterine Contraction / drug effects |
| Chemical | |
Reg. No./Substance:
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23031-25-6/Terbutaline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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