Document Detail

Pharmacokinetics of sulphadimethoxine in channel catfish (Ictalurus punctatus).
MedLine Citation:
PMID:  2075749     Owner:  NLM     Status:  MEDLINE    
1. Plasma clearance, bioavailability, tissue disposition and elimination of 14C-sulphadimethoxine (SDM) were studied in channel catfish (Ictalurus punctatus) after intravenous (i.v.) and oral dosing (per os; p.o.) at 40 mg/kg body weight. 2. Analysis of blood SDM concentrations over time for intravascularly administered SDM showed that disposition and elimination were best described by a two-compartment pharmacokinetic model; estimated half-lives for SDM in blood were 0.09 and 12.6 h for the distribution and elimination phases, respectively. 3. SDM was found primarily in muscle tissue immediately after oral administration; however, clearance from muscle was rapid, with a half-life of 13.1 h. 4. With time, SDM-derived radioactivity became concentrated in the bile and was eliminated slowly (t 1/2 = 115.5 h). 5. Binding of SDM in channel catfish plasma was low (18%) and was non-specific and dose-independent. 6. With the exception of the initial, rapid clearance of SDM from blood, the pharmacokinetic parameters describing SDM distribution and elimination in channel catfish were similar to values reported for other vertebrate species; the rapid distribution of SDM from blood to the tissues in the catfish may be related to species differences in the plasma binding of SDM.
C M Michel; K S Squibb; J M O'Connor
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Xenobiotica; the fate of foreign compounds in biological systems     Volume:  20     ISSN:  0049-8254     ISO Abbreviation:  Xenobiotica     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-04-18     Completed Date:  1991-04-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  1306665     Medline TA:  Xenobiotica     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1299-309     Citation Subset:  IM    
Parke Davis, Warner Lambert Company, Ann Arbor, MI 48105-2340.
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MeSH Terms
Administration, Oral
Bile / metabolism
Carbon Radioisotopes / diagnostic use
Fishes / metabolism
Ictaluridae / metabolism*
Injections, Intravenous
Invertebrates / metabolism
Muscles / metabolism
Sulfadimethoxine / administration & dosage,  blood,  pharmacokinetics*
Time Factors
Tissue Distribution
Vertebrates / metabolism
Grant Support
Reg. No./Substance:
0/Carbon Radioisotopes; 122-11-2/Sulfadimethoxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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