| Pharmacokinetics of sertraline across pregnancy and postpartum. | |
| | |
MedLine Citation:
|
PMID: 19011433 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Insufficient data inform dosing of antidepressants and clinical monitoring for major depressive disorder (MDD) during the perinatal period. The objectives were to assess the pharmacokinetics of sertraline (SER) across pregnancy and postpartum. Participants treated with SER for MDD underwent serial sampling to measure steady-state concentrations of SER and norsertraline during the second and third trimesters and postpartum (total of 3 assessments). Blood was drawn before observed SER administration and 0.5, 1, 2, 4, 6, 8, 10, 12, and 24 hours after administration. A sensitive high-performance liquid chromatography/mass spectrometric method for simultaneous determination of serum concentrations of SER and norsertraline was developed and validated. For each sampling period for SER, area under the serum concentration versus time curve, maximal serum concentration (Cmax), and the time at which Cmax occurred (Tmax) were determined. Of 11 women initially enrolled, 6 completed second- and third-trimester assessments, and 3 completed all 3 assessments (including the postpartum assessment). Mean changes on all pharmacokinetic parameters were nonsignificant between assessments, although there was a marked heterogeneity among individuals. Results were not significantly altered by incorporation of body weights into the analyses. The range of pharmacokinetic changes between individuals was broad, indicating heterogeneity regarding the impact of pregnancy on SER metabolism. Overall, lowest observed SER area under the curve and Cmax occurred in the third trimester (observed in 5 of 6 participants). Despite nonsignificant mean pharmacokinetic changes, the range of pharmacokinetic changes across pregnancy warrants careful monitoring of depressive symptoms in women with MDD in late pregnancy and further study. |
| | |
Authors:
|
Marlene P Freeman; Paul E Nolan; Melinda F Davis; Marietta Anthony; Karen Fried; Martha Fankhauser; Raymond L Woosley; Francisco Moreno |
Related Documents
:
|
12132613 - Changes in gustatory sense during pregnancy. 19499513 - Maternal serum angiopoietin-2 at 11 to 13 weeks of gestation in hypertensive disorders ... 238853 - Beta-adrenergic blockade and atrio--ventricular conduction impairment. |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of clinical psychopharmacology Volume: 28 ISSN: 1533-712X ISO Abbreviation: J Clin Psychopharmacol Publication Date: 2008 Dec |
Date Detail:
|
Created Date: 2008-11-17 Completed Date: 2009-02-02 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8109496 Medline TA: J Clin Psychopharmacol Country: United States |
Other Details:
|
Languages: eng Pagination: 646-53 Citation Subset: IM |
Affiliation:
|
Department of Psychiatry, Women's Mental Health Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA. mfreeman@partners.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
1-Naphthylamine
/
analogs & derivatives,
pharmacokinetics Adult Body Weight Depressive Disorder, Major / drug therapy*, metabolism Female Humans Longitudinal Studies Postpartum Period / metabolism* Pregnancy Pregnancy Complications / drug therapy*, metabolism Pregnancy Trimester, Second / metabolism* Pregnancy Trimester, Third / metabolism* Serotonin Uptake Inhibitors / blood, pharmacokinetics*, therapeutic use Sertraline / blood, pharmacokinetics*, therapeutic use Young Adult |
| Grant Support | |
ID/Acronym/Agency:
|
K23 MH66265/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Serotonin Uptake Inhibitors; 0/norsertraline; 134-32-7/1-Naphthylamine; 79617-96-2/Sertraline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A double-masked, placebo-controlled study of fluoxetine for hypochondriasis.
Next Document: Drugs with anticholinergic properties as a risk factor for cognitive impairment in elderly people: a...