| Pharmacokinetics and safety of high-dose oral acyclovir for suppression of cytomegalovirus disease after renal transplantation. | |
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MedLine Citation:
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PMID: 2840229 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pharmacokinetics and safety of high-dose oral acyclovir for suppression of cytomegalovirus disease were evaluated in 12 patients undergoing renal transplantation. A 12-week course beginning 24 hours before transplantation was administered in doses of 800 to 3200 mg/day based on renal function. Acyclovir plasma concentrations were measured by RIA on posttransplant days 1 or 2 and 5, 6, or 7. Mean peak and trough concentrations on days 5, 6 or 7 were 25 and 18 mumol/L, respectively. The pharmacokinetic model predicted acyclovir concentrations with a precision of 4.1 mumol/L and bias of -1.19 mumol/L. Estimates of individual pharmacokinetic parameters were consistent with literature and a priori values. Two of six adverse events were attributable to acyclovir; both resolved with dose modification. The dosage adjustment scheme and pharmacokinetic model performed well, allowing us to safely administer high-dose oral acyclovir immediately after renal transplantation. We are proceeding with a placebo-controlled study to assess efficacy for suppression of posttransplant cytomegalovirus disease. |
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Authors:
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C V Fletcher; B J Chinnock; B Chace; H H Balfour |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Clinical pharmacology and therapeutics Volume: 44 ISSN: 0009-9236 ISO Abbreviation: Clin. Pharmacol. Ther. Publication Date: 1988 Aug |
Date Detail:
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Created Date: 1988-09-08 Completed Date: 1988-09-08 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372741 Medline TA: Clin Pharmacol Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 158-63 Citation Subset: AIM; IM |
Affiliation:
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Department of Pharmaceutical Services, University of Minnesota, Health Sciences Center, Minneapolis. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acyclovir
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administration & dosage,
blood,
pharmacokinetics* Administration, Oral Adult Cytomegalovirus Infections / prevention & control* Drug Tolerance Female Humans Kidney Transplantation* Male Middle Aged Safety Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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AM13083/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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59277-89-3/Acyclovir |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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