Document Detail


Pharmacokinetics of ricobendazole in calves.
MedLine Citation:
PMID:  11442798     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pharmacokinetics of ricobendazole (RBZ) and its major metabolite albendazole sulphone (ABZSO2) were studied in six calves, after administration of RBZ (7.5 mg/kg), using a 10% experimental solution by the intravenous (i.v.) route, a 10% commercial solution by the subcutaneous (s.c.) route, and a 10% experimental suspension by the intraruminal (i.r.) route. Blood samples were drawn during a 60-h period. Plasma drug and metabolite concentrations were determined by HPLC. The pharmacokinetic evaluation in each case was prepared by weighted least-squares nonlinear regression analysis. Ricobendazole i.v. data were best fitted by a two-compartment model. The best pharmacokinetic exponents and coefficients were estimated, and the pharmacokinetic variables for RBZ and ABZSO2 were calculated from them. Similar patterns of plasma disposition were found for RBZ after i.r. and s.c. administration, suggesting delayed release from the s.c. site resembling the slow release of the drug from the rumen.
Authors:
E A Formentini; O N Mestorino; E L Mariño; J O Errecalde
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of veterinary pharmacology and therapeutics     Volume:  24     ISSN:  0140-7783     ISO Abbreviation:  J. Vet. Pharmacol. Ther.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-07-09     Completed Date:  2001-08-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7910920     Medline TA:  J Vet Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  199-202     Citation Subset:  IM    
Affiliation:
Cátedra de Farmacología, Facultad de Ciencias Veterinarias, Universidad Nacional del Litoral, Esperanza, Argentina.
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MeSH Terms
Descriptor/Qualifier:
Albendazole / administration & dosage,  analogs & derivatives*,  blood,  pharmacokinetics*
Animals
Animals, Newborn / metabolism
Anthelmintics / administration & dosage,  blood,  pharmacokinetics*
Area Under Curve
Cattle / metabolism*
Chromatography, High Pressure Liquid / veterinary
Cross-Over Studies
Injections / veterinary
Injections, Intravenous / veterinary
Injections, Subcutaneous / veterinary
Rumen / metabolism
Chemical
Reg. No./Substance:
0/Anthelmintics; 54029-12-8/albendazole sulfoxide; 54965-21-8/Albendazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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