Document Detail


Pharmacokinetics and residues of a new oral amoxicillin formulation in piglets: a preliminary study.
MedLine Citation:
PMID:  16129343     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pharmacokinetics of amoxicillin (Amx) were determined in pigs following intravenous (IV) administration of a single dose of 15 mg/kg and a single dose of 15 mg/kg of a new oral formulation (Amx-FP containing 10% amoxicillin). Residue studies were performed to determine residues in edible tissues of healthy pigs after chronic oral administration of Amx-FP at a daily dose of 15 mg/kg for five consecutive days. After IV administration, the plasma concentration was characteristic of a two-compartment open model. The main pharmacokinetic variables were: t(1/2lambda(n)), MRT=90.1 min, V(darea)=0.81 L/kg and Cl(b)=3.9 mL/kg/min. After single oral administration the main pharmacokinetic variables were: C(max)=758 mug/L, t(max)=347 min and Cl(b/f)=3.7 mL/kg/min for Amx-FP. The oral bioavailability (F) was calculated at 11% for Amx-FP. Based on maximum residue levels (MRL) for AMX in pigs established at 50 microg/kg for all tissues, the withdrawal times of AMX in muscle and skin plus fat were estimated (95% tolerance limit and 95% confidence) to fall below the MRL after a withdrawal period of seven days. Levels of AMX in the liver and kidneys were estimated to fall below the MRL after a withdrawal period of four days.
Authors:
Esther Hernandez; Raquel Rey; Mariona Puig; Maria Angeles Garcia; Carlos Solans; Miguel Angel Bregante
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Veterinary journal (London, England : 1997)     Volume:  170     ISSN:  1090-0233     ISO Abbreviation:  Vet. J.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-08-30     Completed Date:  2005-10-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9706281     Medline TA:  Vet J     Country:  England    
Other Details:
Languages:  eng     Pagination:  237-42     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Physiology, Faculty of Veterinary Science, University of Zaragoza, Miguel Servet 177, Zaragoza 50013, Spain.
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MeSH Terms
Descriptor/Qualifier:
Amoxicillin / administration & dosage*,  blood,  pharmacokinetics*
Animals
Anti-Bacterial Agents / administration & dosage*,  blood,  pharmacokinetics*
Area Under Curve
Drug Administration Schedule
Drug Residues*
Half-Life
Injections, Intravenous
Swine*
Tissue Distribution
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 26787-78-0/Amoxicillin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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