Document Detail


Pharmacokinetics of propofol infusions in patients with cirrhosis.
MedLine Citation:
PMID:  2223333     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have compared the pharmacokinetics of propofol as an infusion in 10 control and 10 patients with cirrhosis. Anaesthesia was induced within 3-4 min during administration of an infusion of propofol 21 mg kg-1 h-1. After 5 min, the infusion was decreased in a stepwise manner to 12 mg kg-1 h-1 and subsequently 6 mg kg-1 h-1. The mean recovery time after discontinuation of the infusion was significantly longer in the cirrhotic group; however, when patients opened their eyes, blood concentrations of propofol were similar in both groups (1 micrograms ml-1). Pharmacokinetic analysis was performed from the beginning of infusion to 8 h after termination. Total body clearance was not reduced significantly in cirrhotic (1.56 (SD 0.48) litre min-1) compared with control (1.75 (0.32) litre min-1) patients. The volume of distribution at steady state was significantly greater in patients with cirrhosis than in control patients (202 (82) litre vs 121 (49) litre). However, this difference did not change terminal elimination half-life. The pharmacokinetics of propofol given by infusion to maintain general anaesthesia were not affected markedly by moderate cirrhosis.
Authors:
F Servin; I D Cockshott; R Farinotti; J P Haberer; C Winckler; J M Desmonts
Related Documents :
15053753 - The effect of general anesthesia and abdominal surgery upon plasma thromboxane b concen...
3160263 - Anesthesia for termination of pregnancy: midazolam compared with methohexital.
16808613 - Questionnaire- and measurement-based individual thyroid doses in ukraine resulting from...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  65     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-12-11     Completed Date:  1990-12-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  177-83     Citation Subset:  IM    
Affiliation:
Département d'Anesthésie et de Réanimation Chirurgicale, Hôpital Bichat, Paris, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Anesthesia, Intravenous
Humans
Infusions, Intravenous
Liver / metabolism,  surgery
Liver Cirrhosis / metabolism*,  surgery
Middle Aged
Propofol / administration & dosage,  pharmacokinetics*
Chemical
Reg. No./Substance:
2078-54-8/Propofol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of surgery on sensory threshold and somatosensory evoked potentials after skin stimulation.
Next Document:  Effect of propofol on peripheral vascular resistance during cardiopulmonary bypass.