Document Detail

Pharmacokinetics of propofol infusions in patients with cirrhosis.
MedLine Citation:
PMID:  2223333     Owner:  NLM     Status:  MEDLINE    
We have compared the pharmacokinetics of propofol as an infusion in 10 control and 10 patients with cirrhosis. Anaesthesia was induced within 3-4 min during administration of an infusion of propofol 21 mg kg-1 h-1. After 5 min, the infusion was decreased in a stepwise manner to 12 mg kg-1 h-1 and subsequently 6 mg kg-1 h-1. The mean recovery time after discontinuation of the infusion was significantly longer in the cirrhotic group; however, when patients opened their eyes, blood concentrations of propofol were similar in both groups (1 micrograms ml-1). Pharmacokinetic analysis was performed from the beginning of infusion to 8 h after termination. Total body clearance was not reduced significantly in cirrhotic (1.56 (SD 0.48) litre min-1) compared with control (1.75 (0.32) litre min-1) patients. The volume of distribution at steady state was significantly greater in patients with cirrhosis than in control patients (202 (82) litre vs 121 (49) litre). However, this difference did not change terminal elimination half-life. The pharmacokinetics of propofol given by infusion to maintain general anaesthesia were not affected markedly by moderate cirrhosis.
F Servin; I D Cockshott; R Farinotti; J P Haberer; C Winckler; J M Desmonts
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  65     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-12-11     Completed Date:  1990-12-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  177-83     Citation Subset:  IM    
Département d'Anesthésie et de Réanimation Chirurgicale, Hôpital Bichat, Paris, France.
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MeSH Terms
Anesthesia, Intravenous
Infusions, Intravenous
Liver / metabolism,  surgery
Liver Cirrhosis / metabolism*,  surgery
Middle Aged
Propofol / administration & dosage,  pharmacokinetics*
Reg. No./Substance:

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