| Pharmacokinetics of propofol infusions in patients with cirrhosis. | |
MedLine Citation:
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PMID: 2223333 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have compared the pharmacokinetics of propofol as an infusion in 10 control and 10 patients with cirrhosis. Anaesthesia was induced within 3-4 min during administration of an infusion of propofol 21 mg kg-1 h-1. After 5 min, the infusion was decreased in a stepwise manner to 12 mg kg-1 h-1 and subsequently 6 mg kg-1 h-1. The mean recovery time after discontinuation of the infusion was significantly longer in the cirrhotic group; however, when patients opened their eyes, blood concentrations of propofol were similar in both groups (1 micrograms ml-1). Pharmacokinetic analysis was performed from the beginning of infusion to 8 h after termination. Total body clearance was not reduced significantly in cirrhotic (1.56 (SD 0.48) litre min-1) compared with control (1.75 (0.32) litre min-1) patients. The volume of distribution at steady state was significantly greater in patients with cirrhosis than in control patients (202 (82) litre vs 121 (49) litre). However, this difference did not change terminal elimination half-life. The pharmacokinetics of propofol given by infusion to maintain general anaesthesia were not affected markedly by moderate cirrhosis. |
Authors:
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F Servin; I D Cockshott; R Farinotti; J P Haberer; C Winckler; J M Desmonts |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of anaesthesia Volume: 65 ISSN: 0007-0912 ISO Abbreviation: Br J Anaesth Publication Date: 1990 Aug |
Date Detail:
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Created Date: 1990-12-11 Completed Date: 1990-12-11 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 177-83 Citation Subset: IM |
Affiliation:
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Département d'Anesthésie et de Réanimation Chirurgicale, Hôpital Bichat, Paris, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anesthesia, Intravenous Humans Infusions, Intravenous Liver / metabolism, surgery Liver Cirrhosis / metabolism*, surgery Middle Aged Propofol / administration & dosage, pharmacokinetics* |
| Chemical | |
Reg. No./Substance:
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2078-54-8/Propofol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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