| Pharmacokinetics of phenobarbital following single and repeated doses. | |
| | |
MedLine Citation:
|
PMID: 469023 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Serum levels of phenobarbital, and also urinary excretion of phenobarbital and p-hydroxyphenobarbital, were examined after single and repeated oral doses of phenobarbital to three male subjects. Serum levels of phenobarbital at steady state were approximately ten times as high as those after a single dose. The overall elimination rate constant for loss of phenobarbital from serum, Kel, was significantly reduced after repeated doses, and Cmax infinity values calculated from single-dose data poorly predicted observed Cmax infinity values. Five-day urinary excretion of phenobarbital and p-hydroxyphenobarbital accounted for 16 and 21 per cent, respectively, of the initial dose. Due to extensive drug accumulation, 83 per cent of the final dose was excreted in five-day urine as phenobarbital and 85 per cent, as p-hydroxyphenobarbital. Comparison of plasma and renal clearances indicated that the rate of phenobarbital metabolism was reduced owing to repeated dosing, while the rate of urinary excretion of parent drug was unchanged. |
| | |
Authors:
|
C T Viswanathan; H E Booker; P G Welling |
Related Documents
:
|
7987403 - Carbamazepine and cigarette smoking induce differentially the metabolism of codeine in ... 21890023 - Controversy: antenatal steroids. 15752373 - Dosing strategy for enoxaparin in patients with renal impairment presenting with acute ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of clinical pharmacology Volume: 19 ISSN: 0091-2700 ISO Abbreviation: J Clin Pharmacol Publication Date: 1979 May-Jun |
Date Detail:
|
Created Date: 1979-10-17 Completed Date: 1979-10-17 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0366372 Medline TA: J Clin Pharmacol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 282-9 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Half-Life Humans Hydroxylation Kinetics Male Phenobarbital / administration & dosage, metabolism* Time Factors |
| Chemical | |
Reg. No./Substance:
|
50-06-6/Phenobarbital |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Relative bioavailability of quinidine gluconate and quinidine sulfate in healthy volunteers.
Next Document: Interpretation of hematological and biochemical laboratory data in large-scale, multicenter clinical...