Document Detail


Pharmacokinetics of phenobarbital following single and repeated doses.
MedLine Citation:
PMID:  469023     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serum levels of phenobarbital, and also urinary excretion of phenobarbital and p-hydroxyphenobarbital, were examined after single and repeated oral doses of phenobarbital to three male subjects. Serum levels of phenobarbital at steady state were approximately ten times as high as those after a single dose. The overall elimination rate constant for loss of phenobarbital from serum, Kel, was significantly reduced after repeated doses, and Cmax infinity values calculated from single-dose data poorly predicted observed Cmax infinity values. Five-day urinary excretion of phenobarbital and p-hydroxyphenobarbital accounted for 16 and 21 per cent, respectively, of the initial dose. Due to extensive drug accumulation, 83 per cent of the final dose was excreted in five-day urine as phenobarbital and 85 per cent, as p-hydroxyphenobarbital. Comparison of plasma and renal clearances indicated that the rate of phenobarbital metabolism was reduced owing to repeated dosing, while the rate of urinary excretion of parent drug was unchanged.
Authors:
C T Viswanathan; H E Booker; P G Welling
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical pharmacology     Volume:  19     ISSN:  0091-2700     ISO Abbreviation:  J Clin Pharmacol     Publication Date:    1979 May-Jun
Date Detail:
Created Date:  1979-10-17     Completed Date:  1979-10-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0366372     Medline TA:  J Clin Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  282-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Half-Life
Humans
Hydroxylation
Kinetics
Male
Phenobarbital / administration & dosage,  metabolism*
Time Factors
Chemical
Reg. No./Substance:
50-06-6/Phenobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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