Document Detail

Pharmacokinetics of phenobarbital following single and repeated doses.
MedLine Citation:
PMID:  469023     Owner:  NLM     Status:  MEDLINE    
Serum levels of phenobarbital, and also urinary excretion of phenobarbital and p-hydroxyphenobarbital, were examined after single and repeated oral doses of phenobarbital to three male subjects. Serum levels of phenobarbital at steady state were approximately ten times as high as those after a single dose. The overall elimination rate constant for loss of phenobarbital from serum, Kel, was significantly reduced after repeated doses, and Cmax infinity values calculated from single-dose data poorly predicted observed Cmax infinity values. Five-day urinary excretion of phenobarbital and p-hydroxyphenobarbital accounted for 16 and 21 per cent, respectively, of the initial dose. Due to extensive drug accumulation, 83 per cent of the final dose was excreted in five-day urine as phenobarbital and 85 per cent, as p-hydroxyphenobarbital. Comparison of plasma and renal clearances indicated that the rate of phenobarbital metabolism was reduced owing to repeated dosing, while the rate of urinary excretion of parent drug was unchanged.
C T Viswanathan; H E Booker; P G Welling
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical pharmacology     Volume:  19     ISSN:  0091-2700     ISO Abbreviation:  J Clin Pharmacol     Publication Date:    1979 May-Jun
Date Detail:
Created Date:  1979-10-17     Completed Date:  1979-10-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0366372     Medline TA:  J Clin Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  282-9     Citation Subset:  IM    
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MeSH Terms
Phenobarbital / administration & dosage,  metabolism*
Time Factors
Reg. No./Substance:

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