Document Detail


Pharmacokinetics of pheniramine (Avil) and metabolites in healthy subjects after oral and intravenous administration.
MedLine Citation:
PMID:  3988394     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pharmacokinetics of pheniramine and its two metabolites (N-desmethyl pheniramine and N-didesmethyl pheniramine) were determined in six healthy male subjects after intravenous (n = 3) or oral (n = 3) administration (30.5 mg of pheniramine - free base). Serum and urine levels were measured by HPLC. After i.v. administration, serum concentrations of pheniramine between 231 and 894 ng/ml were reached and after oral administration peak serum concentrations between 173 and 274 ng/ml were reached after 1-2.5 h. AUC values up to 72 h were 3035-4662 (i.v.) and 3507-5768 (ng/ml X h) (oral). The terminal half-lives were estimated to range between 8 and 17 h (i.v.) and 16 and 19 h (oral). Serum levels of the N-desmethyl derivative remained very low (up to 21 ng/ml), but were still detectable after 72 h. Serum levels of the N-didesmethyl derivative were below the detection limit. The amount of pheniramine excreted in the urine for up to 120 h varied between 5.7 and 11.6 mg and 10.2 and 13.2 mg after i.v. and oral administration respectively. Unlike the serum, considerable fractions of the drug occurred as metabolites in urine. Values were 8.1-16.4 mg (i.v.) and 7.4-13.3 mg (oral) for N-desmethyl pheniramine, 0.4-2.9 mg (i.v.) and 0.2-0.8 mg (oral) for N-didesmethyl pheniramine.
Authors:
P U Witte; R Irmisch; P Hajdú
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of clinical pharmacology, therapy, and toxicology     Volume:  23     ISSN:  0174-4879     ISO Abbreviation:  Int J Clin Pharmacol Ther Toxicol     Publication Date:  1985 Jan 
Date Detail:
Created Date:  1985-06-06     Completed Date:  1985-06-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8003415     Medline TA:  Int J Clin Pharmacol Ther Toxicol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  59-62     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Biotransformation
Humans
Injections, Intravenous
Kinetics
Male
Middle Aged
Pheniramine / administration & dosage,  analogs & derivatives,  blood,  metabolism*
Chemical
Reg. No./Substance:
19428-44-5/N-desmethylpheniramine; 19428-45-6/N-didesmethylpheniramine; 86-21-5/Pheniramine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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