Document Detail


Pharmacokinetics and pharmacodynamics of rocuronium bromide in adult patients.
MedLine Citation:
PMID:  7925209     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In seven patients (M/F: 4:3) rocuronium 0.6 mg kg-1 was given after the induction of anaesthesia with propofol, and during maintenance with N2O/O2, halothane 0.5% and alfentanil 60-90 micrograms kg-1 h-1. Intubation conditions were scored at 60 s and lag time, onset time, maximal block achieved, recovery to 25% of T1, and Recovery Index, were measured using a Relaxograph. Blood samples were taken over a 300 min period and analysed for rocuronium. Intubating conditions at 60 s were excellent in all patients. Mean clearance was 5.2 ml kg-1 min-1, the terminal half-life was 69 min and distribution volume at steady state was 0.22 litre kg-1. Cumulative urinary excretion was around 18% within 24 h.
Authors:
J A Alvarez-Gomez; M E Estelles; J Fabregat; F Perez; A J Brugger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of anaesthesiology. Supplement     Volume:  9     ISSN:  0952-1941     ISO Abbreviation:  Eur J Anaesthesiol Suppl     Publication Date:  1994  
Date Detail:
Created Date:  1994-11-21     Completed Date:  1994-11-21     Revised Date:  2007-05-23    
Medline Journal Info:
Nlm Unique ID:  8804068     Medline TA:  Eur J Anaesthesiol Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  53-6     Citation Subset:  IM    
Affiliation:
Santa Maria del Rosell Hospital, Cartagena, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adult
Androstanols / pharmacokinetics*,  pharmacology
Anesthesia
Electromyography
Female
Humans
Intubation, Intratracheal
Male
Neuromuscular Junction / drug effects,  physiology
Neuromuscular Nondepolarizing Agents / pharmacokinetics*
Synaptic Transmission / drug effects
Time Factors
Chemical
Reg. No./Substance:
0/Androstanols; 0/Neuromuscular Nondepolarizing Agents; 143558-00-3/rocuronium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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