Document Detail


Pharmacokinetics and pharmacodynamics of pipecuronium bromide (Arduan) in elderly surgical patients.
MedLine Citation:
PMID:  1317685     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The neuromuscular response to pipecuronium bromide (Arduan), 70 micrograms/kg, was studied in 20 elderly (greater than 70 yr) and 10 younger patients (less than 60 yr) during nitrous oxide, fentanyl, and droperidol anesthesia. The adductor pollicis response to single 0.2-ms supramaximal pulses was recorded. Although all younger patients were completely paralyzed, 2 of 20 elderly patients did not attain 90% paralysis. Onset time in the elderly was prolonged (6.9 +/- 2.6 vs 4.3 +/- 1.5 min, P less than 0.02). Spontaneous recovery was similar in both groups, with 75% recovery occurring at 133 +/- 52 min in the elderly and 146 +/- 46 min in the younger patients. The pharmacokinetic variables were similar for the two groups, and pharmacodynamic analysis revealed a similar sensitivity at the neuromuscular junction. The pharmacologic actions of pipecuronium in otherwise healthy patients do not differ between young and elderly adults.
Authors:
E Ornstein; R S Matteo; A E Schwartz; S C Jamdar; J Diaz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  74     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-06-26     Completed Date:  1992-06-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  841-4     Citation Subset:  AIM; IM    
Affiliation:
Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, New York.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aging / metabolism*,  physiology
Androstane-3,17-diol / analogs & derivatives*,  pharmacokinetics,  pharmacology
Humans
Middle Aged
Muscle Relaxants, Central / pharmacokinetics,  pharmacology
Neuromuscular Junction / drug effects
Neuromuscular Nondepolarizing Agents / pharmacokinetics*,  pharmacology
Pipecuronium
Piperazines / pharmacokinetics*,  pharmacology
Sensitivity and Specificity
Surgical Procedures, Operative*
Chemical
Reg. No./Substance:
0/Muscle Relaxants, Central; 0/Neuromuscular Nondepolarizing Agents; 0/Piperazines; 25126-76-5/Androstane-3,17-diol; 68399-58-6/Pipecuronium

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