| Pharmacokinetics and pharmacodynamics of intra-graft iloprost in femorodistal bypass surgery. | |
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MedLine Citation:
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PMID: 9175177 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intra-graft injection of the prostacyclin analogue, iloprost, was performed at the end of femorodistal bypass procedures in 12 patients with severe peripheral arterial occlusive disease. Iloprost plasma levels were measured and compared with changes in haemodynamics. There was a high initial iloprost plasma level (mean 625 pg/ml) which dropped to a mean of 50 pg/ml after 15 min. This correlated with an immediate reduction in systolic blood pressure which had returned to pretreatment levels after 15 min. In contrast, the vascular resistance distal to the graft showed a reduction after 5 min which was maintained for at least 20 min after iloprost injection and the mean blood flow through the graft increased steadily throughout the same period of measurement. The study showed an effect of iloprost on blood pressure which correlated with plasma levels, but the time course of the changes in distal vascular resistance and graft blood flow demonstrated an effect more prolonged than the half-life of iloprost. |
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Authors:
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H R Watson; F C Smith; C P Shearman; M Hildebrand |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and essential fatty acids Volume: 56 ISSN: 0952-3278 ISO Abbreviation: Prostaglandins Leukot. Essent. Fatty Acids Publication Date: 1997 May |
Date Detail:
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Created Date: 1997-07-29 Completed Date: 1997-07-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8802730 Medline TA: Prostaglandins Leukot Essent Fatty Acids Country: SCOTLAND |
Other Details:
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Languages: eng Pagination: 389-93 Citation Subset: IM |
Affiliation:
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Schering AG, Berlin, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Arterial Occlusive Diseases / surgery* Blood Pressure / drug effects Female Femoral Artery / surgery* Half-Life Hemodynamics / drug effects* Humans Iloprost / blood, pharmacokinetics* Male Middle Aged Veins / transplantation* |
| Chemical | |
Reg. No./Substance:
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78919-13-8/Iloprost |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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