| Pharmacokinetics and pharmacodynamics of Org NC 45 in man. | |
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MedLine Citation:
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PMID: 6107104 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A combined pharmacokinetic--pharmacodynamic study of Org NC 45 was performed in six patients undergoing elective oro--facial surgery. The pharmacokinetics could be described using a two-compartment open model with a distribution half-life of approximately 4 min and an elimination half-life of approximately 31 min. The pharmacokinetic parameters confirm earlier clinical findings that Org NC 45 has a more rapid onset and a shorter duration of action than pancuronium, and a faster recovery rate. When comparing the pharmacokinetic and pharmacodynamic parameters the biophase could be distinguished from both the central and the peripheral compartments. The mean steady-state plasma concentration producing a 50% block of the twitch response was 0.137 microgram ml-1 (range 0.118--0.176 microgram ml-1). |
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Authors:
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F van der Veen; A Bencini |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of anaesthesia Volume: 52 Suppl 1 ISSN: 0007-0912 ISO Abbreviation: Br J Anaesth Publication Date: 1980 |
Date Detail:
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Created Date: 1981-01-16 Completed Date: 1981-01-16 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 37S-41S Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Female Half-Life Humans Kinetics Male Models, Biological Neuromuscular Junction / drug effects Pancuronium / analogs & derivatives*, blood, pharmacology Time Factors Vecuronium Bromide |
| Chemical | |
Reg. No./Substance:
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0/Pancuronium; 50700-72-6/Vecuronium Bromide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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