Document Detail


Pharmacokinetics of paeoniflorin after oral administration of Shao-yao Gan-chao Tang in mice.
MedLine Citation:
PMID:  11949878     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Paeoniflorin, a monoterpene glycoside, is the principal bioactive component of Paeoniae Radix. The traditional prescription Shao-yao Gan-chao Tang (SGT; Kampo: Shakuyaku-Kanzo-To), which is composed of Paeoniae Radix and Glycyrrhizae Radix, has been widely used in China and Japan. Quantification of paeoniflorin in mouse plasma after oral administration of SGT (at a dose containing 10 mg/kg paeoniflorin) was achieved using a simple and rapid high-performance liquid chromatography method. The plasma concentration-time curves were fitted with mean terminal half-lives (t 1/2) of 116.17 min. The maximum plasma concentration (Cmax) of paeoniflorin was 111.56 ng/ml, time to reach maximum concentration (tmax) was 17.00 min, the area under the plasma concentration-time curve (AUC)0-t was 12293.42 ng x min/ml, clearance/bioavailability (CL/F) value was 644.74 ml/min x kg, apparent volume of distribution/ bioavailability (Vd/F) value was 103.05 l/kg, and the mean residence time (MRT) was 169.64 min. These results, together with the previously reported kinetic data of paeoniflorin after oral administration of Paeoniae Radix extract alone, indicated that absorption of paeoniflorin after oral administration of SGT was significantly greater than that after oral administration of Paeoniae Radix alone.
Authors:
Lih-Chi Chen; Mei-Huei Chou; Ming-Fang Lin; Ling-Ling Yang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Japanese journal of pharmacology     Volume:  88     ISSN:  0021-5198     ISO Abbreviation:  Jpn. J. Pharmacol.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-04-12     Completed Date:  2002-10-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2983305R     Medline TA:  Jpn J Pharmacol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  250-5     Citation Subset:  IM    
Affiliation:
Department of Pharmacognosy, Graduate Institute of Pharmaceutical Sciences, Taipei Medical University, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics*
Area Under Curve
Benzoic Acids*
Bridged Compounds*
Calibration
Chromatography, High Pressure Liquid
Freeze Drying
Glucosides / pharmacokinetics*
Half-Life
Male
Mice
Mice, Inbred ICR
Plant Extracts / pharmacokinetics
Reproducibility of Results
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Benzoic Acids; 0/Bridged Compounds; 0/Glucosides; 0/Plant Extracts; 23180-57-6/peoniflorin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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