Document Detail


Pharmacokinetics of oseltamivir among pregnant and nonpregnant women.
MedLine Citation:
PMID:  21492826     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We sought to delineate the pharmacokinetics (PK) of oseltamivir and its active metabolite oseltamivir carboxylate during pregnancy. Physiologic changes of pregnancy, including increased renal filtration and secretion, may increase the clearance of oseltamivir carboxylate. Sixteen pregnant women taking oseltamivir for prophylaxis or treatment of suspected/proven influenza infection were enrolled. Twenty-three nonpregnant reproductive-age females served as the control group. The primary PK endpoint was area under the plasma concentration time curve for oseltamivir carboxylate. Pregnancy did not alter the PK parameters of the parent compound, oseltamivir. However, for oseltamivir carboxylate the area under the plasma concentration time curve was significantly lower (P = .007) and the apparent clearance significantly higher (P = .006) in pregnant women compared with nonpregnant women. Pregnancy produces lower systemic levels of oseltamivir carboxylate. Increasing the dose and/or dosing frequency of oseltamivir during pregnancy may be necessary to achieve comparable exposure in pregnant and nonpregnant women.
Authors:
Richard H Beigi; Kelong Han; Raman Venkataramanan; Gary D Hankins; Shannon Clark; Mary F Hebert; Thomas Easterling; Anne Zajicek; Zhaoxia Ren; Donald R Mattison; Steve N Caritis;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural     Date:  2011-03-09
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  204     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-06     Completed Date:  2011-06-23     Revised Date:  2014-05-08    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S84-8     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 Mosby, Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antibiotic Prophylaxis
Antiviral Agents / pharmacokinetics*,  therapeutic use
Area Under Curve
Case-Control Studies
Female
Humans
Influenza, Human / blood,  drug therapy*
Metabolic Clearance Rate
Oseltamivir / analogs & derivatives,  blood,  pharmacokinetics*,  therapeutic use
Pregnancy / blood,  physiology*
Pregnancy Complications, Infectious / blood,  drug therapy*
Young Adult
Grant Support
ID/Acronym/Agency:
HD047891/HD/NICHD NIH HHS; HD047892/HD/NICHD NIH HHS; HD047905/HD/NICHD NIH HHS; U10 HD047905/HD/NICHD NIH HHS; U10 HD047905-01/HD/NICHD NIH HHS; UL1RR025014/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/oseltamivir carboxylate; 20O93L6F9H/Oseltamivir
Comments/Corrections
Comment In:
Am J Obstet Gynecol. 2011 Jun;204(6 Suppl 1):S94-5   [PMID:  21640232 ]

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